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ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ. Hirschenberger M, et al. Among authors: kirchhoff f. Nat Commun. 2023 Nov 1;14(1):6770. doi: 10.1038/s41467-023-42150-4. Nat Commun. 2023. PMID: 37914730 Free PMC article.
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.
Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Usmani SM, et al. Among authors: kirchhoff f. Nat Commun. 2014 Apr 1;5:3508. doi: 10.1038/ncomms4508. Nat Commun. 2014. PMID: 24691351 Free PMC article.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R. Thoms M, et al. Among authors: kirchhoff f. Science. 2020 Sep 4;369(6508):1249-1255. doi: 10.1126/science.abc8665. Epub 2020 Jul 17. Science. 2020. PMID: 32680882 Free PMC article.
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. Volcic M, et al. Among authors: kirchhoff f. Nat Microbiol. 2020 Oct;5(10):1247-1261. doi: 10.1038/s41564-020-0753-6. Epub 2020 Jul 20. Nat Microbiol. 2020. PMID: 32690953
Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.
Hayn M, Blötz A, Rodríguez A, Vidal S, Preising N, Ständker L, Wiese S, Stürzel CM, Harms M, Gross R, Jung C, Kiene M, Jacob T, Pöhlmann S, Forssmann WG, Münch J, Sparrer KMJ, Seuwen K, Hahn BH, Kirchhoff F. Hayn M, et al. Among authors: kirchhoff f. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2023776118. doi: 10.1073/pnas.2023776118. Proc Natl Acad Sci U S A. 2021. PMID: 33431697 Free PMC article.
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. Müller JA, et al. Among authors: kirchhoff f. Nat Metab. 2021 Feb;3(2):149-165. doi: 10.1038/s42255-021-00347-1. Epub 2021 Feb 3. Nat Metab. 2021. PMID: 33536639
517 results