Kirabo A - Search Results

1

Recent Advances in Understanding Peripheral and Gut Immune Cell-Mediated Salt-Sensitive Hypertension and Nephropathy.

Saleem M, Masenga SK, Ishimwe JA, Demirci M, Ahmad T, Jamison S, Albritton CF, Mwesigwa N, Porcia Haynes A, White J, Neikirk K, Vue Z, Hinton A Jr, Arshad S, Desta S, Kirabo A. Saleem M, et al. Among authors: kirabo a. Hypertension. 2024 Mar;81(3):436-446. doi: 10.1161/HYPERTENSIONAHA.123.22031. Epub 2024 Jan 2. Hypertension. 2024. PMID: 38164753 Free article. Review.

2

The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.

Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keserű GM, Cogle CR, Sayeski PP. Kirabo A, et al. Am J Pathol. 2012 Sep;181(3):858-65. doi: 10.1016/j.ajpath.2012.05.033. Epub 2012 Jul 13. Am J Pathol. 2012. PMID: 22796437 Free PMC article.

3

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Wu J, et al. Among authors: kirabo a. J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. J Clin Invest. 2016. PMID: 27035819 Free PMC article. No abstract available.

4

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

Kiss R, Polgár T, Kirabo A, Sayyah J, Figueroa NC, List AF, Sokol L, Zuckerman KS, Gali M, Bisht KS, Sayeski PP, Keseru GM. Kiss R, et al. Among authors: kirabo a. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601. doi: 10.1016/j.bmcl.2009.04.138. Epub 2009 May 5. Bioorg Med Chem Lett. 2009. PMID: 19447617 Free PMC article.

5

The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

Kirabo A, Park SO, Majumder A, Gali M, Reinhard MK, Wamsley HL, Zhao ZJ, Cogle CR, Bisht KS, Keserü GM, Sayeski PP. Kirabo A, et al. Neoplasia. 2011 Nov;13(11):1058-68. doi: 10.1593/neo.111112. Neoplasia. 2011. PMID: 22131881 Free PMC article.

6

Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.

Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS. Saleh MA, et al. Among authors: kirabo a. J Clin Invest. 2015 Mar 2;125(3):1189-202. doi: 10.1172/JCI76327. Epub 2015 Feb 9. J Clin Invest. 2015. PMID: 25664851 Free PMC article.

7

Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.

Kirabo A, Ryzhov S, Gupte M, Sengsayadeth S, Gumina RJ, Sawyer DB, Galindo CL. Kirabo A, et al. J Mol Cell Cardiol. 2017 Apr;105:59-69. doi: 10.1016/j.yjmcc.2017.03.001. Epub 2017 Mar 3. J Mol Cell Cardiol. 2017. PMID: 28263756 Free PMC article.

8

A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.

Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: kirabo a. Exp Hematol. 2012 Jan;40(1):22-34. doi: 10.1016/j.exphem.2011.10.003. Epub 2011 Oct 20. Exp Hematol. 2012. PMID: 22019628 Free PMC article.

9

Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.

McDoom I, Ma X, Kirabo A, Lee KY, Ostrov DA, Sayeski PP. McDoom I, et al. Among authors: kirabo a. Biochemistry. 2008 Aug 12;47(32):8326-34. doi: 10.1021/bi800867d. Epub 2008 Jul 18. Biochemistry. 2008. PMID: 18636744 Free PMC article.

10

The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.

Kirabo A, Embury J, Kiss R, Polgár T, Gali M, Majumder A, Bisht KS, Cogle CR, Keseru GM, Sayeski PP. Kirabo A, et al. J Biol Chem. 2011 Feb 11;286(6):4280-91. doi: 10.1074/jbc.M110.200774. Epub 2010 Dec 2. J Biol Chem. 2011. PMID: 21127060 Free PMC article.

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