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DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens.
Al-Khrasani M, Spetea M, Friedmann T, Riba P, Király K, Schmidhammer H, Furst S. Al-Khrasani M, et al. Among authors: kiraly k. Brain Res Bull. 2007 Oct 19;74(5):369-75. doi: 10.1016/j.brainresbull.2007.07.008. Epub 2007 Jul 30. Brain Res Bull. 2007. PMID: 17845912
Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.
Spetea M, Windisch P, Guo Y, Bileviciute-Ljungar I, Schütz J, Asim MF, Berzetei-Gurske IP, Riba P, Kiraly K, Fürst S, Al-Khrasani M, Schmidhammer H. Spetea M, et al. Among authors: kiraly k. J Med Chem. 2011 Feb 24;54(4):980-8. doi: 10.1021/jm101211p. Epub 2011 Jan 14. J Med Chem. 2011. PMID: 21235243 Free PMC article.
131 results