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Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5.
Rinné S, Kiper AK, Jacob R, Ortiz-Bonnin B, Schindler RFR, Fischer S, Komadowski M, De Martino E, Schäfer MK, Cornelius T, Fabritz L, Helker CSM, Brand T, Decher N. Rinné S, et al. Among authors: kiper ak. iScience. 2024 Apr 9;27(5):109696. doi: 10.1016/j.isci.2024.109696. eCollection 2024 May 17. iScience. 2024. PMID: 38689644 Free PMC article.
Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.
Schreiber JA, Derksen A, Goerges G, Schütte S, Sörgel J, Kiper AK, Strutz-Seebohm N, Ruck T, Meuth SG, Decher N, Seebohm G. Schreiber JA, et al. Among authors: kiper ak. Commun Biol. 2023 Jul 18;6(1):745. doi: 10.1038/s42003-023-05114-4. Commun Biol. 2023. PMID: 37464013 Free PMC article.
Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability.
Arévalo B, Bedoya M, Kiper AK, Vergara F, Ramírez D, Mazola Y, Bustos D, Zúñiga R, Cikutovic R, Cayo A, Rinné S, Ramirez-Apan MT, Sepúlveda FV, Cerda O, López-Collazo E, Decher N, Zúñiga L, Gutierrez M, González W. Arévalo B, et al. Among authors: kiper ak. J Med Chem. 2022 Nov 24;65(22):15014-15027. doi: 10.1021/acs.jmedchem.1c00378. Epub 2022 Nov 15. J Med Chem. 2022. PMID: 36378530
A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.
Valdés-Jiménez A, Jiménez-González D, Kiper AK, Rinné S, Decher N, González W, Reyes-Parada M, Núñez-Vivanco G. Valdés-Jiménez A, et al. Among authors: kiper ak. Front Pharmacol. 2022 Mar 18;13:855792. doi: 10.3389/fphar.2022.855792. eCollection 2022. Front Pharmacol. 2022. PMID: 35370665 Free PMC article.
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.
Matschke LA, Komadowski MA, Stöhr A, Lee B, Henrich MT, Griesbach M, Rinné S, Geibl FF, Chiu WH, Koprich JB, Brotchie JM, Kiper AK, Dolga AM, Oertel WH, Decher N. Matschke LA, et al. Among authors: kiper ak. Sci Rep. 2022 Feb 24;12(1):3180. doi: 10.1038/s41598-022-06832-1. Sci Rep. 2022. PMID: 35210472 Free PMC article.
40 results