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Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.
Khan MR, Yin X, Kang SU, Mitra J, Wang H, Ryu T, Brahmachari S, Karuppagounder SS, Kimura Y, Jhaldiyal A, Kim HH, Gu H, Chen R, Redding-Ochoa J, Troncoso J, Na CH, Ha T, Dawson VL, Dawson TM. Khan MR, et al. Among authors: kimura y. Sci Transl Med. 2023 Nov 29;15(724):eadd0499. doi: 10.1126/scitranslmed.add0499. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019930
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Zhang S, Liu YQ, Jia C, Lim YJ, Feng G, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu JJ, Ma MR, Liu Z, Jiang L, Li D, Wang R, Dawson VL, Dawson TM, Li YM, Mao X, Liu C. Zhang S, et al. Among authors: kimura y. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2011196118. doi: 10.1073/pnas.2011196118. Proc Natl Acad Sci U S A. 2021. PMID: 34172566 Free PMC article.
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
Choong CJ, Aguirre C, Kakuda K, Beck G, Nakanishi H, Kimura Y, Shimma S, Nabekura K, Hideshima M, Doi J, Yamaguchi K, Nakajima K, Wadayama T, Hayakawa H, Baba K, Ogawa K, Takeuchi T, Badawy SMM, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nagai Y, Mochizuki H, Ikenaka K. Choong CJ, et al. Among authors: kimura y. Acta Neuropathol. 2023 May;145(5):573-595. doi: 10.1007/s00401-023-02555-3. Epub 2023 Mar 20. Acta Neuropathol. 2023. PMID: 36939875 Free PMC article.
Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.
Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H. Kakuda K, et al. Among authors: kimura y. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2312306120. doi: 10.1073/pnas.2312306120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147546 Free PMC article.
Extracellular transportation of α-synuclein by HLA class II molecules.
Ozono T, Kimura Y, Suenaga T, Beck G, Jinno J, Aguirre C, Ikenaka K, Krainc D, Mochizuki H, Arase H. Ozono T, et al. Among authors: kimura y. Biochem Biophys Res Commun. 2023 Feb 12;644:25-33. doi: 10.1016/j.bbrc.2022.12.082. Epub 2022 Dec 31. Biochem Biophys Res Commun. 2023. PMID: 36621149
5,842 results