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Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
Watanabe T, Igarashi M, Okajima T, Ishii E, Kino H, Hatano M, Sawa R, Umekita M, Kimura T, Okamoto S, Eguchi Y, Akamatsu Y, Utsumi R. Watanabe T, et al. Among authors: kimura t. Antimicrob Agents Chemother. 2012 Jul;56(7):3657-63. doi: 10.1128/AAC.06467-11. Epub 2012 Apr 23. Antimicrob Agents Chemother. 2012. PMID: 22526318 Free PMC article.
Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.
Igarashi M, Watanabe T, Hashida T, Umekita M, Hatano M, Yanagida Y, Kino H, Kimura T, Kinoshita N, Inoue K, Sawa R, Nishimura Y, Utsumi R, Nomoto A. Igarashi M, et al. Among authors: kimura t. J Antibiot (Tokyo). 2013 Aug;66(8):459-64. doi: 10.1038/ja.2013.33. Epub 2013 May 1. J Antibiot (Tokyo). 2013. PMID: 23632918
An unusual terpene cyclization mechanism involving a carbon-carbon bond rearrangement.
Meguro A, Motoyoshi Y, Teramoto K, Ueda S, Totsuka Y, Ando Y, Tomita T, Kim SY, Kimura T, Igarashi M, Sawa R, Shinada T, Nishiyama M, Kuzuyama T. Meguro A, et al. Among authors: kimura t. Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4353-6. doi: 10.1002/anie.201411923. Epub 2015 Feb 16. Angew Chem Int Ed Engl. 2015. PMID: 25689152
New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.
Atsumi S, Nosaka C, Adachi H, Kimura T, Kobayashi Y, Takada H, Watanabe T, Ohba S, Inoue H, Kawada M, Shibasaki M, Shibuya M. Atsumi S, et al. Among authors: kimura t. BMC Cancer. 2016 Jul 19;16:496. doi: 10.1186/s12885-016-2521-9. BMC Cancer. 2016. PMID: 27431653 Free PMC article.
Metacytofilin Is a Potent Therapeutic Drug Candidate for Toxoplasmosis.
Leesombun A, Iijima M, Umeda K, Kondoh D, Pagmadulam B, Abdou AM, Suzuki Y, Ohba SI, Isshiki K, Kimura T, Kubota Y, Sawa R, Nihei CI, Nishikawa Y. Leesombun A, et al. Among authors: kimura t. J Infect Dis. 2020 Feb 18;221(5):766-774. doi: 10.1093/infdis/jiz501. J Infect Dis. 2020. PMID: 31573038
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