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Page 1
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors.
Rubbini G, Buades-Martín AB, Kimatrai-Salvador M, Entrena A, Gallo-Mezo MÁ, Ríos-Marco P, Marco C, Mattiuzzo E, Bortolozzi R, Mariotto E, Greco FA, Macchiarulo A, Carrasco-Jiménez MP, Viola G, López-Cara LC. Rubbini G, et al. Among authors: kimatrai salvador m. Future Med Chem. 2018 Aug 1;10(15):1769-1786. doi: 10.4155/fmc-2018-0059. Epub 2018 Jul 25. Future Med Chem. 2018. PMID: 30043647
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Romagnoli R, Prencipe F, Oliva P, Baraldi S, Baraldi PG, Schiaffino Ortega S, Chayah M, Kimatrai Salvador M, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Mattiuzzo E, Viola G. Romagnoli R, et al. Among authors: kimatrai salvador m. J Med Chem. 2019 Feb 14;62(3):1274-1290. doi: 10.1021/acs.jmedchem.8b01391. Epub 2019 Jan 18. J Med Chem. 2019. PMID: 30633509 Free article.
Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.
Romagnoli R, Baraldi PG, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, Brancale A, Hamel E, Castagliuolo I, Bortolozzi R, Basso G, Viola G. Romagnoli R, et al. Among authors: kimatrai salvador m. J Med Chem. 2013 Mar 28;56(6):2606-18. doi: 10.1021/jm400043d. Epub 2013 Mar 18. J Med Chem. 2013. PMID: 23445496 Free PMC article.
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G. Romagnoli R, et al. Among authors: kimatrai salvador m. Eur J Med Chem. 2018 Jan 1;143:683-698. doi: 10.1016/j.ejmech.2017.11.096. Eur J Med Chem. 2018. PMID: 29220790 Free PMC article.
Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors.
Schiaffino-Ortega S, Mariotto E, Luque-Navarro PM, Kimatrai-Salvador M, Rios-Marco P, Hurtado-Guerrero R, Marco C, Carrasco-Jimenez MP, Viola G, López-Cara LC. Schiaffino-Ortega S, et al. Among authors: kimatrai salvador m. Pharmaceutics. 2021 Aug 29;13(9):1360. doi: 10.3390/pharmaceutics13091360. Pharmaceutics. 2021. PMID: 34575436 Free PMC article.
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.
Romagnoli R, Prencipe F, Oliva P, Kimatrai Salvador M, Brancale A, Ferla S, Hamel E, Viola G, Bortolozzi R, Persoons L, Balzarini J, Liekens S, Schols D. Romagnoli R, et al. Among authors: kimatrai salvador m. Bioorg Chem. 2020 Apr;97:103665. doi: 10.1016/j.bioorg.2020.103665. Epub 2020 Feb 18. Bioorg Chem. 2020. PMID: 32086053 Free article.
One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.
Romagnoli R, Baraldi PG, Lopez Cara C, Kimatrai Salvador M, Bortolozzi R, Basso G, Viola G, Balzarini J, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E. Romagnoli R, et al. Among authors: kimatrai salvador m. Eur J Med Chem. 2011 Dec;46(12):6015-24. doi: 10.1016/j.ejmech.2011.10.013. Epub 2011 Oct 15. Eur J Med Chem. 2011. PMID: 22027100 Free PMC article.
1 H and 13 C NMR spectral assignments of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives.
Schiaffino-Ortega S, Kimatrai-Salvador M, Baglioni E, Gallo MA, Entrena Guadix A, Lopez-Cara LC. Schiaffino-Ortega S, et al. Among authors: kimatrai salvador m. Magn Reson Chem. 2016 Nov;54(11):905-911. doi: 10.1002/mrc.4468. Epub 2016 Jul 11. Magn Reson Chem. 2016. PMID: 27402422 No abstract available.
Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor.
Romagnoli R, Baraldi PG, Carrion MD, Lopez Cara C, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Moorman AR, Vincenzi F, Borea PA, Varani K. Romagnoli R, et al. Among authors: kimatrai salvador m. Eur J Med Chem. 2013 Sep;67:409-27. doi: 10.1016/j.ejmech.2013.07.002. Epub 2013 Jul 13. Eur J Med Chem. 2013. PMID: 23911855
Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis.
Romagnoli R, Baraldi PG, Lopez-Cara C, Cruz-Lopez O, Carrion MD, Kimatrai Salvador M, Bermejo J, Estévez S, Estévez F, Balzarini J, Brancale A, Ricci A, Chen L, Kim JG, Hamel E. Romagnoli R, et al. ChemMedChem. 2011 Oct 4;6(10):1841-53. doi: 10.1002/cmdc.201100279. Epub 2011 Aug 1. ChemMedChem. 2011. PMID: 21805646 Free PMC article.
11 results