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Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats.
Hsueh HT, Chou RT, Rai U, Kolodziejski P, Liyanage W, Pejavar J, Mozzer A, Davison C, Appell MB, Kim YC, Leo KT, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Pitha I, Zack DJ, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: kim yc. J Control Release. 2023 Oct;362:371-380. doi: 10.1016/j.jconrel.2023.08.058. Epub 2023 Sep 4. J Control Release. 2023. PMID: 37657693
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells.
Kim YC, Hsueh HT, Shin MD, Berlinicke CA, Han H, Anders NM, Hemingway A, Leo KT, Chou RT, Kwon H, Appell MB, Rai U, Kolodziejski P, Eberhart C, Pitha I, Zack DJ, Hanes J, Ensign LM. Kim YC, et al. Drug Deliv Transl Res. 2022 Apr;12(4):826-837. doi: 10.1007/s13346-021-00987-6. Epub 2021 Apr 26. Drug Deliv Transl Res. 2022. PMID: 33900546 Free PMC article.
Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells.
Hsueh HT, Kim YC, Pitha I, Shin MD, Berlinicke CA, Chou RT, Kimball E, Schaub J, Quillen S, Leo KT, Han H, Xiao A, Kim Y, Appell M, Rai U, Kwon H, Kolodziejski P, Ogunnaike L, Anders NM, Hemingway A, Jefferys JL, Date AA, Eberhart C, Johnson TV, Quigley HA, Zack DJ, Hanes J, Ensign LM. Hsueh HT, et al. Among authors: kim yc, kim y. Pharmaceutics. 2021 May 1;13(5):647. doi: 10.3390/pharmaceutics13050647. Pharmaceutics. 2021. PMID: 34062883 Free PMC article.
Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery.
Hsueh HT, Chou RT, Rai U, Liyanage W, Kim YC, Appell MB, Pejavar J, Leo KT, Davison C, Kolodziejski P, Mozzer A, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Edwards M, Pitha I, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: kim yc. Nat Commun. 2023 May 2;14(1):2509. doi: 10.1038/s41467-023-38056-w. Nat Commun. 2023. PMID: 37130851 Free PMC article.
Gelling hypotonic polymer solution for extended topical drug delivery to the eye.
Kim YC, Shin MD, Hackett SF, Hsueh HT, Lima E Silva R, Date A, Han H, Kim BJ, Xiao A, Kim Y, Ogunnaike L, Anders NM, Hemingway A, He P, Jun AS, McDonnell PJ, Eberhart C, Pitha I, Zack DJ, Campochiaro PA, Hanes J, Ensign LM. Kim YC, et al. Among authors: kim bj, kim y. Nat Biomed Eng. 2020 Nov;4(11):1053-1062. doi: 10.1038/s41551-020-00606-8. Epub 2020 Sep 7. Nat Biomed Eng. 2020. PMID: 32895514 Free PMC article.
Sustained delivery of acriflavine from the suprachoroidal space provides long term suppression of choroidal neovascularization.
Hackett SF, Fu J, Kim YC, Tsujinaka H, Shen J, Lima E Silva R, Khan M, Hafiz Z, Wang T, Shin M, Anders NM, He P, Ensign LM, Hanes J, Campochiaro PA. Hackett SF, et al. Among authors: kim yc. Biomaterials. 2020 Jun;243:119935. doi: 10.1016/j.biomaterials.2020.119935. Epub 2020 Mar 4. Biomaterials. 2020. PMID: 32172031 Free PMC article.
Strategy to enhance dendritic cell-mediated DNA vaccination in the lung.
Kim YC, Hsueh HT, Kim N, Rodriguez J, Leo KT, Rao D, West NE, Hanes J, Suk JS. Kim YC, et al. Among authors: kim n. Adv Ther (Weinh). 2021 Feb;4(2):2000228. doi: 10.1002/adtp.202000228. Epub 2021 Feb 24. Adv Ther (Weinh). 2021. PMID: 33709020 Free PMC article.
Ocular delivery of macromolecules.
Kim YC, Chiang B, Wu X, Prausnitz MR. Kim YC, et al. J Control Release. 2014 Sep 28;190:172-81. doi: 10.1016/j.jconrel.2014.06.043. Epub 2014 Jul 3. J Control Release. 2014. PMID: 24998941 Free PMC article. Review.
3,218 results