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Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
Kang SY, Park EJ, Park WK, Kim HJ, Jeong D, Jung ME, Song KS, Lee SH, Seo HJ, Kim MJ, Lee M, Han HK, Son EJ, Pae AN, Kim J, Lee J. Kang SY, et al. Among authors: kim hj, kim j, kim mj. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1705-11. doi: 10.1016/j.bmcl.2010.01.093. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20149649
Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist.
Lee J, Seo HJ, Lee SH, Kim J, Jung ME, Lee SH, Song KS, Lee J, Kang SY, Kim MJ, Kim MS, Son EJ, Lee M, Han HK. Lee J, et al. Among authors: kim ms, kim j, kim mj. Bioorg Med Chem. 2010 Sep 1;18(17):6377-88. doi: 10.1016/j.bmc.2010.07.013. Epub 2010 Jul 30. Bioorg Med Chem. 2010. PMID: 20673729
Pentacycle derivatives as cannabinoid CB1 receptor ligands.
Lee SH, Seo HJ, Kim MJ, Kang SY, Lee SH, Ahn K, Lee M, Han HK, Kim J, Lee J. Lee SH, et al. Among authors: kim j, kim mj. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6632-6. doi: 10.1016/j.bmcl.2009.10.015. Epub 2009 Oct 8. Bioorg Med Chem Lett. 2009. PMID: 19850473
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