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Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: kim jh. Sci Transl Med. 2023 Jan 11;15(678):eabo0205. doi: 10.1126/scitranslmed.abo0205. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630481
IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.
Allinne J, Scott G, Lim WK, Birchard D, Erjefält JS, Sandén C, Ben LH, Agrawal A, Kaur N, Kim JH, Kamat V, Fury W, Huang T, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Allinne J, et al. Among authors: kim jh. J Allergy Clin Immunol. 2019 Dec;144(6):1624-1637.e10. doi: 10.1016/j.jaci.2019.08.039. Epub 2019 Sep 25. J Allergy Clin Immunol. 2019. PMID: 31562870 Free article.
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: kim jh. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine.
Hovhannisyan Z, Liu N, Khalil-Aguero S, Panea C, VanValkenburgh J, Zhang R, Lim WK, Bai Y, Fury W, Huang T, Garnova E, Fairhurst J, Kim J, Aryal S, Ajithdoss D, Oyejide A, Del Pilar Molina-Portela M, E H, Poueymirou W, Oristian NS, Brydges S, Liu X, Olson W, Yancopoulos G, Murphy AJ, Sleeman MA, Haxhinasto S. Hovhannisyan Z, et al. Sci Immunol. 2020 Dec 18;5(54):eaax1686. doi: 10.1126/sciimmunol.aax1686. Sci Immunol. 2020. PMID: 33443029
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA. Altarejos JY, et al. Among authors: kim s, kim jh. Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992152 Clinical Trial.
A wirelessly programmable, skin-integrated thermo-haptic stimulator system for virtual reality.
Kim JH, Vázquez-Guardado A, Luan H, Kim JT, Yang DS, Zhang H, Chang JK, Yoo S, Park C, Wei Y, Christiansen Z, Kim S, Avila R, Kim JU, Lee YJ, Shin HS, Zhou M, Jeon SW, Baek JM, Lee Y, Kim SY, Lim J, Park M, Jeong H, Won SM, Chen R, Huang Y, Jung YH, Yoo JY, Rogers JA. Kim JH, et al. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2404007121. doi: 10.1073/pnas.2404007121. Epub 2024 May 20. Proc Natl Acad Sci U S A. 2024. PMID: 38768347
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