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Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.
Takwale AD, Kim EY, Jang Y, Lee DH, Kim S, Choi Y, Kim JH, Lee DY, Kim Y, Lee SM, Lee HK, Nam HJ, Lee JY, Cho JH, Moon JH, Lee GS, Kim JH, Kim P, Park CH, Hwang JY. Takwale AD, et al. Among authors: kim ey, kim s, kim p, kim y, kim jh. Bioorg Chem. 2022 Oct;127:105923. doi: 10.1016/j.bioorg.2022.105923. Epub 2022 Jun 13. Bioorg Chem. 2022. PMID: 35717803 Free article.
Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL.
Yoon MK, Kim BY, Lee JY, Ha JH, Kim SA, Lee DH, Lee MS, Lee MK, Choi JS, Cho JH, Kim JH, Kim S, Song J, Park SG, Park BC, Bae KH, Choi SU, Chi SW. Yoon MK, et al. Among authors: kim s, kim by, kim sa, kim jh. J Biol Chem. 2018 Dec 21;293(51):19546-19558. doi: 10.1074/jbc.RA118.003061. Epub 2018 Nov 14. J Biol Chem. 2018. PMID: 30429221 Free PMC article.
A novel cereblon modulator for targeted protein degradation.
Kim SA, Go A, Jo SH, Park SJ, Jeon YU, Kim JE, Lee HK, Park CH, Lee CO, Park SG, Kim P, Park BC, Cho SY, Kim S, Ha JD, Kim JH, Hwang JY. Kim SA, et al. Among authors: kim s, kim p, kim je, kim jh. Eur J Med Chem. 2019 Mar 15;166:65-74. doi: 10.1016/j.ejmech.2019.01.023. Epub 2019 Jan 17. Eur J Med Chem. 2019. PMID: 30684871
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Cho JH, Kim K, Kim SA, Park S, Park BO, Kim JH, Kim SY, Kwon MJ, Han MH, Lee SB, Park BC, Park SG, Kim JH, Kim S. Cho JH, et al. Among authors: kim sy, kim s, kim k, kim sa, kim jh. Cell Death Differ. 2021 Mar;28(3):900-914. doi: 10.1038/s41418-020-00649-z. Epub 2020 Oct 27. Cell Death Differ. 2021. PMID: 33110214 Free PMC article.
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