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EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML. Needham SR, et al. Among authors: kim et. Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. Nat Commun. 2016. PMID: 27796308 Free PMC article.
How does a drug molecule find its target binding site?
Shan Y, Kim ET, Eastwood MP, Dror RO, Seeliger MA, Shaw DE. Shan Y, et al. Among authors: kim et. J Am Chem Soc. 2011 Jun 22;133(24):9181-3. doi: 10.1021/ja202726y. Epub 2011 May 13. J Am Chem Soc. 2011. PMID: 21545110 Free PMC article.
Transitions to catalytically inactive conformations in EGFR kinase.
Shan Y, Arkhipov A, Kim ET, Pan AC, Shaw DE. Shan Y, et al. Among authors: kim et. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7270-5. doi: 10.1073/pnas.1220843110. Epub 2013 Apr 1. Proc Natl Acad Sci U S A. 2013. PMID: 23576739 Free PMC article.
How does a small molecule bind at a cryptic binding site?
Shan Y, Mysore VP, Leffler AE, Kim ET, Sagawa S, Shaw DE. Shan Y, et al. Among authors: kim et. PLoS Comput Biol. 2022 Mar 3;18(3):e1009817. doi: 10.1371/journal.pcbi.1009817. eCollection 2022 Mar. PLoS Comput Biol. 2022. PMID: 35239648 Free PMC article.
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR. Shan Y, et al. Among authors: kim et. Nat Struct Mol Biol. 2014 Jul;21(7):579-84. doi: 10.1038/nsmb.2849. Epub 2014 Jun 11. Nat Struct Mol Biol. 2014. PMID: 24918548 Free PMC article.
Regulation of RAS oncogenicity by acetylation.
Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Yang MH, et al. Among authors: kim et. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18. Proc Natl Acad Sci U S A. 2012. PMID: 22711838 Free PMC article.
199 results