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Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice.
Helsley RN, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang EC, Banerjee R, Brown AL, Fung KK, Massey WJ, Neumann C, Orabi D, Osborn LJ, Schugar RC, McMullen MR, Bellar A, Poulsen KL, Kim A, Pathak V, Mrdjen M, Anderson JT, Willard B, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Garcia-Garcia JC, Rotroff DM, Allende DS, Wang Z, Hazen SL, Nagy LE, Brown JM. Helsley RN, et al. Among authors: kim a. Elife. 2022 Jan 27;11:e76554. doi: 10.7554/eLife.76554. Elife. 2022. PMID: 35084335 Free PMC article.
Hepatic Immune System: Adaptations to Alcohol.
Kim A, McCullough RL, Poulsen KL, Sanz-Garcia C, Sheehan M, Stavitsky AB, Nagy LE. Kim A, et al. Handb Exp Pharmacol. 2018;248:347-367. doi: 10.1007/164_2017_88. Handb Exp Pharmacol. 2018. PMID: 29374837 Review.
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.
Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID, Dasarathy S. Kant S, et al. Among authors: kim a. J Biol Chem. 2019 May 3;294(18):7231-7244. doi: 10.1074/jbc.RA118.005411. Epub 2019 Mar 14. J Biol Chem. 2019. PMID: 30872403 Free PMC article.
Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.
Davuluri G, Giusto M, Chandel R, Welch N, Alsabbagh K, Kant S, Kumar A, Kim A, Gangadhariah M, Ghosh PK, Tran U, Krajcik DM, Vasu K, DiDonato AJ, DiDonato JA, Willard B, Monga SP, Wang Y, Fox PL, Stark GR, Wessely O, Esser KA, Dasarathy S. Davuluri G, et al. Among authors: kim a. Mol Cell Biol. 2019 Jul 29;39(16):e00451-18. doi: 10.1128/MCB.00451-18. Print 2019 Aug 15. Mol Cell Biol. 2019. PMID: 31138664 Free PMC article.
Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.
Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S. Kumar A, et al. Among authors: kim a. Free Radic Biol Med. 2019 Dec;145:284-299. doi: 10.1016/j.freeradbiomed.2019.09.031. Epub 2019 Sep 28. Free Radic Biol Med. 2019. PMID: 31574345 Free PMC article.
7,188 results