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Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M, Coelho A, Krämer A, Saxena A, Sabatier P, Beusch CM, Lönnblom E, Geng M, Do NN, Xu Z, Zhang J, He Y, Romero Castillo L, Abolhassani H, Xu B, Viljanen J, Rorbach J, Fernandez Lahore G, Gjertsson I, Kastbom A, Sjöwall C, Kihlberg J, Zubarev RA, Burkhardt H, Holmdahl R. Aoun M, et al. Among authors: kihlberg j. J Exp Med. 2023 Nov 6;220(11):e20230101. doi: 10.1084/jem.20230101. Epub 2023 Sep 11. J Exp Med. 2023. PMID: 37695523 Free PMC article.
A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis.
Tong D, Lönnblom E, Yau ACY, Nandakumar KS, Liang B, Ge C, Viljanen J, Li L, Bãlan M, Klareskog L, Chagin AS, Gjertsson I, Kihlberg J, Zhao M, Holmdahl R. Tong D, et al. Among authors: kihlberg j. Front Immunol. 2018 Apr 12;9:451. doi: 10.3389/fimmu.2018.00451. eCollection 2018. Front Immunol. 2018. PMID: 29706949 Free PMC article.
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ge C, Weisse S, Xu B, Dobritzsch D, Viljanen J, Kihlberg J, Do NN, Schneider N, Lanig H, Holmdahl R, Burkhardt H. Ge C, et al. Among authors: kihlberg j. Ann Rheum Dis. 2022 Apr;81(4):480-489. doi: 10.1136/annrheumdis-2021-220500. Epub 2022 Jan 13. Ann Rheum Dis. 2022. PMID: 35027402 Free PMC article.
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
Tengvall S, Eneljung T, Jirholt P, Turesson O, Wing K, Holmdahl R, Kihlberg J, Stern A, Mårtensson IL, Henningsson L, Gustafsson K, Gjertsson I. Tengvall S, et al. Among authors: kihlberg j. PLoS One. 2016 May 9;11(5):e0154630. doi: 10.1371/journal.pone.0154630. eCollection 2016. PLoS One. 2016. PMID: 27159398 Free PMC article.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. Ge C, et al. Among authors: kihlberg j. JCI Insight. 2017 Jul 6;2(13):e93688. doi: 10.1172/jci.insight.93688. eCollection 2017 Jul 6. JCI Insight. 2017. PMID: 28679953 Free PMC article.
201 results