Kihlberg J - Search Results

1

Docking Finds GPCR Ligands in Dark Chemical Matter.

Ballante F, Rudling A, Zeifman A, Luttens A, Vo DD, Irwin JJ, Kihlberg J, Brea J, Loza MI, Carlsson J. Ballante F, et al. Among authors: kihlberg j. J Med Chem. 2020 Jan 23;63(2):613-620. doi: 10.1021/acs.jmedchem.9b01560. Epub 2020 Jan 13. J Med Chem. 2020. PMID: 31846328

2

Conformations and receptor activity of desmopressin analogues, which contain gamma-turn mimetics or a psi[CH(2)O] isostere.

Hedenström M, Yuan Z, Brickmann K, Carlsson J, Ekholm K, Johansson B, Kreutz E, Nilsson A, Sethson I, Kihlberg J. Hedenström M, et al. Among authors: kihlberg j. J Med Chem. 2002 Jun 6;45(12):2501-11. doi: 10.1021/jm011073b. J Med Chem. 2002. PMID: 12036358

3

Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold.

Saitton S, Del Tredici AL, Mohell N, Vollinga RC, Boström D, Kihlberg J, Luthman K. Saitton S, et al. Among authors: kihlberg j. J Med Chem. 2004 Dec 16;47(26):6595-602. doi: 10.1021/jm049484q. J Med Chem. 2004. PMID: 15588094

4

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli.

Larsson A, Johansson SM, Pinkner JS, Hultgren SJ, Almqvist F, Kihlberg J, Linusson A. Larsson A, et al. Among authors: kihlberg j. J Med Chem. 2005 Feb 24;48(4):935-45. doi: 10.1021/jm040818l. J Med Chem. 2005. PMID: 15715464

5

Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis.

Holm L, Frech K, Dzhambazov B, Holmdahl R, Kihlberg J, Linusson A. Holm L, et al. Among authors: kihlberg j. J Med Chem. 2007 May 3;50(9):2049-59. doi: 10.1021/jm061209b. Epub 2007 Apr 11. J Med Chem. 2007. PMID: 17425295

6

3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS.

Berggren K, Vindebro R, Bergström C, Spoerry C, Persson H, Fex T, Kihlberg J, von Pawel-Rammingen U, Luthman K. Berggren K, et al. Among authors: kihlberg j. J Med Chem. 2012 Mar 22;55(6):2549-60. doi: 10.1021/jm201517a. Epub 2012 Mar 14. J Med Chem. 2012. PMID: 22369147 Free PMC article.

7

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

Over B, McCarren P, Artursson P, Foley M, Giordanetto F, Grönberg G, Hilgendorf C, Lee MD 4th, Matsson P, Muncipinto G, Pellisson M, Perry MW, Svensson R, Duvall JR, Kihlberg J. Over B, et al. Among authors: kihlberg j. J Med Chem. 2014 Mar 27;57(6):2746-54. doi: 10.1021/jm500059t. Epub 2014 Feb 26. J Med Chem. 2014. PMID: 24524242 Free PMC article.

8

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Doak BC, Zheng J, Dobritzsch D, Kihlberg J. Doak BC, et al. Among authors: kihlberg j. J Med Chem. 2016 Mar 24;59(6):2312-27. doi: 10.1021/acs.jmedchem.5b01286. Epub 2015 Oct 30. J Med Chem. 2016. PMID: 26457449 Review.

9

How Big Is Too Big for Cell Permeability?

Matsson P, Kihlberg J. Matsson P, et al. Among authors: kihlberg j. J Med Chem. 2017 Mar 9;60(5):1662-1664. doi: 10.1021/acs.jmedchem.7b00237. Epub 2017 Feb 24. J Med Chem. 2017. PMID: 28234469

10

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

Rossi Sebastiano M, Doak BC, Backlund M, Poongavanam V, Over B, Ermondi G, Caron G, Matsson P, Kihlberg J. Rossi Sebastiano M, et al. Among authors: kihlberg j. J Med Chem. 2018 May 10;61(9):4189-4202. doi: 10.1021/acs.jmedchem.8b00347. Epub 2018 Apr 16. J Med Chem. 2018. PMID: 29608068 Free article.

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