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Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.
Kanada R, Kagoshima Y, Asano M, Suzuki T, Murata T, Haruta M, Takahashi M, Ubukata O, Hashimoto K, Obata K, Kihara K, Kuroha M, Banjo T, Togashi N, Sato K, Yamamoto Y, Suzuki K, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: kihara k. Bioorg Med Chem Lett. 2022 Jun 15;66:128726. doi: 10.1016/j.bmcl.2022.128726. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413416
Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Kanada R, Kagoshima Y, Suzuki T, Nakamura A, Funami H, Watanabe J, Asano M, Takahashi M, Ubukata O, Suzuki K, Aikawa T, Sato K, Goto M, Setsu G, Ito K, Kihara K, Kuroha M, Kohno T, Ogiwara H, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: kihara k. J Med Chem. 2023 Jan 12;66(1):695-715. doi: 10.1021/acs.jmedchem.2c01641. Epub 2022 Dec 26. J Med Chem. 2023. PMID: 36572866
Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.
Makinoya M, Miyatani K, Matsumi Y, Sakano Y, Shimizu S, Shishido Y, Hanaki T, Kihara K, Matsunaga T, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Saito H, Nakayama Y, Osaki M, Okada F, Fujiwara Y. Makinoya M, et al. Among authors: kihara k. Sci Rep. 2024 May 2;14(1):10075. doi: 10.1038/s41598-024-60967-x. Sci Rep. 2024. PMID: 38698201 Free PMC article.
Investigating the efficacy and safety of olanzapine prophylaxis for opioid-induced nausea and vomiting (JORTC-PAL20): a study protocol for an open-label, single-arm exploratory study.
Satomi E, Kobayashi T, Ishikawa A, Arakawa S, Ishiki H, Amano K, Sakiyama N, Ariyoshi K, Kihara K, Oyamada S, Mizushima A. Satomi E, et al. Among authors: kihara k. BMJ Open. 2024 Feb 27;14(2):e076575. doi: 10.1136/bmjopen-2023-076575. BMJ Open. 2024. PMID: 38417963 Free PMC article.
A gastroduodenal artery that branched from the celiac artery in gastrectomy: A rare case of an anatomical variant.
Shimizu S, Matsunaga T, Sakano Y, Makinoya M, Shishido Y, Miyatani K, Kono Y, Murakami Y, Hanaki T, Kihara K, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Fujiwara Y. Shimizu S, et al. Among authors: kihara k. Asian J Endosc Surg. 2024 Jan;17(1):e13268. doi: 10.1111/ases.13268. Epub 2023 Dec 13. Asian J Endosc Surg. 2024. PMID: 38093466
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H. Shimizu M, et al. Among authors: kihara k. Sci Adv. 2023 Nov 24;9(47):eadg3193. doi: 10.1126/sciadv.adg3193. Epub 2023 Nov 22. Sci Adv. 2023. PMID: 37992159 Free PMC article.
Skeletal Muscle Mass Before Second-line Chemotherapy Correlates With Subsequent Prognosis and Rate of Late-line Chemotherapy in Patients With Unresectable Gastric Cancer.
Matsunaga T, Satio H, Sakano YU, Makinoya M, Shimizu S, Shishido Y, Miyatani K, Kono Y, Murakami Y, Hanaki T, Kihara K, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Fujiwara Y. Matsunaga T, et al. Among authors: kihara k. Anticancer Res. 2023 Nov;43(11):5051-5059. doi: 10.21873/anticanres.16704. Anticancer Res. 2023. PMID: 37909949
700 results