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The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.
Cristóvão JS, Morris VK, Cardoso I, Leal SS, Martínez J, Botelho HM, Göbl C, David R, Kierdorf K, Alemi M, Madl T, Fritz G, Reif B, Gomes CM. Cristóvão JS, et al. Among authors: kierdorf k. Sci Adv. 2018 Jun 29;4(6):eaaq1702. doi: 10.1126/sciadv.aaq1702. eCollection 2018 Jun. Sci Adv. 2018. PMID: 29963623 Free PMC article.
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M. Kierdorf K, et al. Nat Neurosci. 2013 Mar;16(3):273-80. doi: 10.1038/nn.3318. Epub 2013 Jan 20. Nat Neurosci. 2013. PMID: 23334579
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M. Goldmann T, et al. Among authors: kierdorf k. EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20. EMBO J. 2015. PMID: 25896511 Free PMC article.
Microglia contribute to the propagation of Aβ into unaffected brain tissue.
d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M. d'Errico P, et al. Among authors: kierdorf k. Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22. Nat Neurosci. 2022. PMID: 34811521 Free PMC article.
A lineage of myeloid cells independent of Myb and hematopoietic stem cells.
Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F. Schulz C, et al. Among authors: kierdorf k. Science. 2012 Apr 6;336(6077):86-90. doi: 10.1126/science.1219179. Epub 2012 Mar 22. Science. 2012. PMID: 22442384
Factors regulating microglia activation.
Kierdorf K, Prinz M. Kierdorf K, et al. Front Cell Neurosci. 2013 Apr 23;7:44. doi: 10.3389/fncel.2013.00044. eCollection 2013. Front Cell Neurosci. 2013. PMID: 23630462 Free PMC article.
47 results