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Designed SARS-CoV-2 receptor binding domain variants form stable monomers.
Klausberger M, Kienzl NF, Stadlmayr G, Grünwald-Gruber C, Laurent E, Stadlbauer K, Stracke F, Vierlinger K, Hofner M, Manhart G, Gerner W, Grebien F, Weinhäusel A, Mach L, Wozniak-Knopp G. Klausberger M, et al. Among authors: kienzl nf. Biotechnol J. 2022 May;17(5):e2100422. doi: 10.1002/biot.202100422. Epub 2022 Feb 3. Biotechnol J. 2022. PMID: 35078277 Free PMC article.
Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana.
Castilho A, Schwestka J, Kienzl NF, Vavra U, Grünwald-Gruber C, Izadi S, Hiremath C, Niederhöfer J, Laurent E, Monteil V, Mirazimi A, Wirnsberger G, Stadlmann J, Stöger E, Mach L, Strasser R. Castilho A, et al. Among authors: kienzl nf. Biotechnol J. 2021 Jun;16(6):e2000566. doi: 10.1002/biot.202000566. Epub 2021 Feb 12. Biotechnol J. 2021. PMID: 33481336 Free PMC article.
N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in Plants.
Shin YJ, König-Beihammer J, Vavra U, Schwestka J, Kienzl NF, Klausberger M, Laurent E, Grünwald-Gruber C, Vierlinger K, Hofner M, Margolin E, Weinhäusel A, Stöger E, Mach L, Strasser R. Shin YJ, et al. Among authors: kienzl nf. Front Plant Sci. 2021 Jun 15;12:689104. doi: 10.3389/fpls.2021.689104. eCollection 2021. Front Plant Sci. 2021. PMID: 34211491 Free PMC article.
Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays.
Schwestka J, König-Beihammer J, Shin YJ, Vavra U, Kienzl NF, Grünwald-Gruber C, Maresch D, Klausberger M, Laurent E, Stadler M, Manhart G, Huber J, Hofner M, Vierlinger K, Weinhäusel A, Swoboda I, Binder CJ, Gerner W, Grebien F, Altmann F, Mach L, Stöger E, Strasser R. Schwestka J, et al. Among authors: kienzl nf. Front Plant Sci. 2021 Sep 27;12:747500. doi: 10.3389/fpls.2021.747500. eCollection 2021. Front Plant Sci. 2021. PMID: 34646292 Free PMC article.
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.
Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J. Capraz T, et al. Among authors: kienzl nf. Elife. 2021 Dec 20;10:e73641. doi: 10.7554/eLife.73641. Elife. 2021. PMID: 34927585 Free PMC article.
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P. Zhu R, et al. Among authors: kienzl nf. Nat Commun. 2022 Dec 24;13(1):7926. doi: 10.1038/s41467-022-35641-3. Nat Commun. 2022. PMID: 36566234 Free PMC article.
Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P. Zhu R, et al. Among authors: kienzl nf. Nat Commun. 2023 Feb 28;14(1):1142. doi: 10.1038/s41467-023-36905-2. Nat Commun. 2023. PMID: 36854739 Free PMC article. No abstract available.
Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential.
Paumann-Page M, Kienzl NF, Motwani J, Bathish B, Paton LN, Magon NJ, Sevcnikar B, Furtmüller PG, Traxlmayr MW, Obinger C, Eccles MR, Winterbourn CC. Paumann-Page M, et al. Among authors: kienzl nf. Redox Biol. 2021 Oct;46:102090. doi: 10.1016/j.redox.2021.102090. Epub 2021 Aug 4. Redox Biol. 2021. PMID: 34438259 Free PMC article.