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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Selvarajan I, Kiema M, Huang RT, Li J, Zhu J, Pölönen P, Örd T, Õunap K, Godiwala M, Golebiewski AK, Ravindran A, Mäklin K, Toropainen A, Stolze LK, Arce M, Magnusson PU, White S, Romanoski CE, Heinäniemi M, Laakkonen JP, Fang Y, Kaikkonen-Määttä M. Selvarajan I, et al. Among authors: kiema m. Arterioscler Thromb Vasc Biol. 2024 Apr 11. doi: 10.1161/ATVBAHA.123.318964. Online ahead of print. Arterioscler Thromb Vasc Biol. 2024. PMID: 38602103 Free article.
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Ravindran A, Holappa L, Niskanen H, Skovorodkin I, Kaisto S, Beter M, Kiema M, Selvarajan I, Nurminen V, Aavik E, Aherrahrou R, Pasonen-Seppänen S, Fortino V, Laakkonen JP, Ylä-Herttuala S, Vainio S, Örd T, Kaikkonen MU. Ravindran A, et al. Among authors: kiema m. Cardiovasc Res. 2024 Jan 30:cvae028. doi: 10.1093/cvr/cvae028. Online ahead of print. Cardiovasc Res. 2024. PMID: 38289873
ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.
Jauhiainen S, Ilmonen H, Vuola P, Rasinkangas H, Pulkkinen HH, Keränen S, Kiema M, Liikkanen JJ, Laham-Karam N, Laidinen S, Beter M, Aavik E, Lappalainen K, Lohi J, Aronniemi J, Örd T, Kaikkonen MU, Salminen P, Tukiainen E, Ylä-Herttuala S, Laakkonen JP. Jauhiainen S, et al. Among authors: kiema m. Elife. 2023 May 18;12:e82543. doi: 10.7554/eLife.82543. Elife. 2023. PMID: 37199488 Free PMC article.
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.
Örd T, Lönnberg T, Nurminen V, Ravindran A, Niskanen H, Kiema M, Õunap K, Maria M, Moreau PR, Mishra PP, Palani S, Virta J, Liljenbäck H, Aavik E, Roivainen A, Ylä-Herttuala S, Laakkonen JP, Lehtimäki T, Kaikkonen MU. Örd T, et al. Among authors: kiema m. Am J Hum Genet. 2023 May 4;110(5):722-740. doi: 10.1016/j.ajhg.2023.03.013. Epub 2023 Apr 14. Am J Hum Genet. 2023. PMID: 37060905 Free PMC article.
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms.
Jauhiainen S, Kiema M, Hedman M, Laakkonen JP. Jauhiainen S, et al. Among authors: kiema m. Arterioscler Thromb Vasc Biol. 2022 Jul;42(7):811-818. doi: 10.1161/ATVBAHA.121.316237. Epub 2022 May 19. Arterioscler Thromb Vasc Biol. 2022. PMID: 35587695 Free article. Review.
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
Pulkkinen HH, Kiema M, Lappalainen JP, Toropainen A, Beter M, Tirronen A, Holappa L, Niskanen H, Kaikkonen MU, Ylä-Herttuala S, Laakkonen JP. Pulkkinen HH, et al. Among authors: kiema m. Angiogenesis. 2021 Feb;24(1):129-144. doi: 10.1007/s10456-020-09748-4. Epub 2020 Oct 6. Angiogenesis. 2021. PMID: 33021694 Free PMC article.