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Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Antibiotics (Basel). 2021 Jan 21;10(2):103. doi: 10.3390/antibiotics10020103.
Antibiotics (Basel). 2021.
PMID: 33494538
Free PMC article.
Review.
Enzyme targets for drug design of new anti-virulence therapeutics.
Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A.
Kahler CM, et al. Among authors: kibble ea.
Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/j.sbi.2018.08.010. Epub 2018 Sep 14.
Curr Opin Struct Biol. 2018.
PMID: 30223251
Free article.
Review.
Item in Clipboard
The Detroit 562 Pharyngeal Immortalized Cell Line Model for the Assessment of Infectivity of Pathogenic Neisseria sp.
Kibble EA, Sarkar-Tyson M, Coombs GW, Kahler CM.
Kibble EA, et al.
Methods Mol Biol. 2019;1969:123-133. doi: 10.1007/978-1-4939-9202-7_9.
Methods Mol Biol. 2019.
PMID: 30877674
Item in Clipboard
Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
Scheuplein NJ, Bzdyl NM, Kibble EA, Lohr T, Holzgrabe U, Sarkar-Tyson M.
Scheuplein NJ, et al. Among authors: kibble ea.
J Med Chem. 2020 Nov 25;63(22):13355-13388. doi: 10.1021/acs.jmedchem.0c00911. Epub 2020 Aug 28.
J Med Chem. 2020.
PMID: 32786507
Review.
Item in Clipboard
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major.
Iwasaki J, Lorimer DD, Vivoli-Vega M, Kibble EA, Peacock CS, Abendroth J, Mayclin SJ, Dranow DM, Pierce PG, Fox D, Lewis M, Bzdyl NM, Kristensen SS, Inglis TJJ, Kahler CM, Bond CS, Hasenkopf A, Seufert F, Schmitz J, Marshall LE, Scott AE, Norville IH, Myler PJ, Holzgrabe U, Harmer NJ, Sarkar-Tyson M.
Iwasaki J, et al. Among authors: kibble ea.
J Antimicrob Chemother. 2022 May 29;77(6):1625-1634. doi: 10.1093/jac/dkac065.
J Antimicrob Chemother. 2022.
PMID: 35245364
Free PMC article.
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Analysis of Structure-Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei.
Scheuplein NJ, Bzdyl NM, Lohr T, Kibble EA, Hasenkopf A, Herbst C, Sarkar-Tyson M, Holzgrabe U.
Scheuplein NJ, et al. Among authors: kibble ea.
J Med Chem. 2023 Jul 13;66(13):8876-8895. doi: 10.1021/acs.jmedchem.3c00458. Epub 2023 Jun 30.
J Med Chem. 2023.
PMID: 37389560
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Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis.
Debowski AW, Bzdyl NM, Thomas DR, Scott NE, Jenkins CH, Iwasaki J, Kibble EA, Khoo CA, Scheuplein NJ, Seibel PM, Lohr T, Metters G, Bond CS, Norville IH, Stubbs KA, Harmer NJ, Holzgrabe U, Newton HJ, Sarkar-Tyson M.
Debowski AW, et al. Among authors: kibble ea.
PLoS Pathog. 2023 Jul 3;19(7):e1011491. doi: 10.1371/journal.ppat.1011491. eCollection 2023 Jul.
PLoS Pathog. 2023.
PMID: 37399210
Free PMC article.
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