Kiakos K - Search Results

1

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.

Howard TT, Lingerfelt BM, Purnell BL, Scott AE, Price CA, Townes HM, McNulty L, Handl HL, Summerville K, Hudson SJ, Bowen JP, Kiakos K, Hartley JA, Lee M. Howard TT, et al. Among authors: kiakos k. Bioorg Med Chem. 2002 Sep;10(9):2941-52. doi: 10.1016/s0968-0896(02)00157-8. Bioorg Med Chem. 2002. PMID: 12110316

2

Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.

Toth JL, Price CA, Madsen EC, Handl HL, Hudson SJ, Hubbard RB 3rd, Bowen JP, Kiakos K, Hartley JA, Lee M. Toth JL, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2245-8. doi: 10.1016/s0960-894x(02)00341-4. Bioorg Med Chem Lett. 2002. PMID: 12127548

3

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.

Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M. Kupchinsky S, et al. Among authors: kiakos k. Bioorg Med Chem. 2004 Dec 1;12(23):6221-36. doi: 10.1016/j.bmc.2004.08.051. Bioorg Med Chem. 2004. PMID: 15519165

4

Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.

Daniell K, Stewart M, Madsen E, Le M, Handl H, Brooks N, Kiakos K, Hartley JA, Lee M. Daniell K, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2005 Jan 3;15(1):177-80. doi: 10.1016/j.bmcl.2004.10.021. Bioorg Med Chem Lett. 2005. PMID: 15582435

5

Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole-imidazole polyamides.

Price CA, Lingerfelt BM, Handl HL, Kiakos K, Hartley JA, Lee M. Price CA, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3151-6. doi: 10.1016/j.bmcl.2005.04.006. Bioorg Med Chem Lett. 2005. PMID: 15876536

6

A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.

Sato A, McNulty L, Cox K, Kim S, Scott A, Daniell K, Summerville K, Price C, Hudson S, Kiakos K, Hartley JA, Asao T, Lee M. Sato A, et al. Among authors: kiakos k. J Med Chem. 2005 Jun 2;48(11):3903-18. doi: 10.1021/jm050179u. J Med Chem. 2005. PMID: 15916443

7

Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.

Purnell B, Lingerfelt B, Scott A, Townes H, Summerville K, Hudson S, Kiakos K, Hartley JA, Lee M. Purnell B, et al. Among authors: kiakos k. Med Chem. 2006 Mar;2(2):139-46. doi: 10.2174/157340606776056188. Med Chem. 2006. PMID: 16787363

8

A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.

Toth JL, Trzupek JD, Flores LV, Kiakos K, Hartley JA, Pennington WT, Lee M. Toth JL, et al. Among authors: kiakos k. Med Chem. 2005 Jan;1(1):13-9. doi: 10.2174/1573406053402523. Med Chem. 2005. PMID: 16789881

9

DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

Purnell B, Sato A, O'kelley A, Price C, Summerville K, Hudson S, O'hare C, Kiakos K, Asao T, Lee M, Hartley JA. Purnell B, et al. Among authors: kiakos k. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5677-81. doi: 10.1016/j.bmcl.2006.08.005. Epub 2006 Aug 21. Bioorg Med Chem Lett. 2006. PMID: 16919946

10

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

Chavda S, Babu B, Yanow SK, Jardim A, Spithill TW, Kiakos K, Kluza J, Hartley JA, Lee M. Chavda S, et al. Among authors: kiakos k. Bioorg Med Chem. 2010 Jul 15;18(14):5016-24. doi: 10.1016/j.bmc.2010.05.078. Epub 2010 Jun 4. Bioorg Med Chem. 2010. PMID: 20579889

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