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Rational siRNA design for RNA interference.
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Reynolds A, et al. Among authors: khvorova a. Nat Biotechnol. 2004 Mar;22(3):326-30. doi: 10.1038/nbt936. Epub 2004 Feb 1. Nat Biotechnol. 2004. PMID: 14758366 Free article.
A combinatorial approach for achieving CNS-selective RNAi.
Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. Ferguson CM, et al. Among authors: khvorova a. Nucleic Acids Res. 2024 Feb 13:gkae100. doi: 10.1093/nar/gkae100. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38348876
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Hariharan VN, et al. Among authors: khvorova a. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219523120. doi: 10.1073/pnas.2219523120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893269 Free PMC article.
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo.
Hariharan VN, Caiazzi J, Miller R, Ferguson C, Sapp E, Fakih H, Tang Q, Yamada N, Furgal R, Paquette J, Bramato B, McHugh N, Summers A, Lochmann C, Godinho B, Hildebrand S, Echeverria D, Hassler M, Alterman J, DiFiglia M, Aronin N, Khvorova A, Yamada K. Hariharan VN, et al. Among authors: khvorova a. Res Sq [Preprint]. 2023 Jun 1:rs.3.rs-2987323. doi: 10.21203/rs.3.rs-2987323/v1. Res Sq. 2023. PMID: 37398145 Free PMC article. Preprint.
Functional siRNAs and miRNAs exhibit strand bias.
Khvorova A, Reynolds A, Jayasena SD. Khvorova A, et al. Cell. 2003 Oct 17;115(2):209-16. doi: 10.1016/s0092-8674(03)00801-8. Cell. 2003. PMID: 14567918 Free article.
142 results