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An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW. Luo S, et al. Among authors: khurana s. Sci Immunol. 2022 Oct 28;7(76):eadd5446. doi: 10.1126/sciimmunol.add5446. Epub 2022 Aug 11. Sci Immunol. 2022. PMID: 35951767 Free PMC article.
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.
Whittle JR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC. Whittle JR, et al. Among authors: khurana s. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14216-21. doi: 10.1073/pnas.1111497108. Epub 2011 Aug 8. Proc Natl Acad Sci U S A. 2011. PMID: 21825125 Free PMC article.
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.
Moody MA, Zhang R, Walter EB, Woods CW, Ginsburg GS, McClain MT, Denny TN, Chen X, Munshaw S, Marshall DJ, Whitesides JF, Drinker MS, Amos JD, Gurley TC, Eudailey JA, Foulger A, DeRosa KR, Parks R, Meyerhoff RR, Yu JS, Kozink DM, Barefoot BE, Ramsburg EA, Khurana S, Golding H, Vandergrift NA, Alam SM, Tomaras GD, Kepler TB, Kelsoe G, Liao HX, Haynes BF. Moody MA, et al. Among authors: khurana s. PLoS One. 2011;6(10):e25797. doi: 10.1371/journal.pone.0025797. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22039424 Free PMC article.
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC. Schmidt AG, et al. Among authors: khurana s. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):264-9. doi: 10.1073/pnas.1218256109. Epub 2012 Nov 21. Proc Natl Acad Sci U S A. 2013. PMID: 23175789 Free PMC article.
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Saunders KO, Lee E, Parks R, Martinez DR, Li D, Chen H, Edwards RJ, Gobeil S, Barr M, Mansouri K, Alam SM, Sutherland LL, Cai F, Sanzone AM, Berry M, Manne K, Bock KW, Minai M, Nagata BM, Kapingidza AB, Azoitei M, Tse LV, Scobey TD, Spreng RL, Rountree RW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Tang J, Oguin TH 3rd, Sempowski GD, Gagne M, Douek DC, Tomai MA, Fox CB, Seder R, Wiehe K, Weissman D, Pardi N, Golding H, Khurana S, Acharya P, Andersen H, Lewis MG, Moore IN, Montefiori DC, Baric RS, Haynes BF. Saunders KO, et al. Among authors: khurana s. Nature. 2021 Jun;594(7864):553-559. doi: 10.1038/s41586-021-03594-0. Epub 2021 May 10. Nature. 2021. PMID: 33971664 Free PMC article.
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19.
Ravichandran S, Tang J, Grubbs G, Lee Y, Pourhashemi S, Hussaini L, Lapp SA, Jerris RC, Singh V, Chahroudi A, Anderson EJ, Rostad CA, Khurana S. Ravichandran S, et al. Among authors: khurana s. Nat Immunol. 2021 Nov;22(11):1452-1464. doi: 10.1038/s41590-021-01051-8. Epub 2021 Oct 5. Nat Immunol. 2021. PMID: 34611361
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS. Martinez DR, et al. Among authors: khurana s. Sci Transl Med. 2022 Jan 26;14(629):eabj7125. doi: 10.1126/scitranslmed.abj7125. Epub 2022 Jan 26. Sci Transl Med. 2022. PMID: 34726473 Free PMC article.
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.
Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek DC, DeMarco CT, Denny TN, Oguin TH 3rd, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai MA, Fox CB, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Baric RS, Montefiori DC, Saunders KO, Haynes BF. Li D, et al. Among authors: khurana s. bioRxiv [Preprint]. 2022 Feb 14:2022.01.26.477915. doi: 10.1101/2022.01.26.477915. bioRxiv. 2022. PMID: 35118474 Free PMC article. Updated. Preprint.
1,084 results