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Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Tansley S, et al. Among authors: khoutorsky a. Nat Commun. 2022 Feb 11;13(1):843. doi: 10.1038/s41467-022-28473-8. Nat Commun. 2022. PMID: 35149686 Free PMC article.
Multifaceted regulation of somatic cell reprogramming by mRNA translational control.
Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N. Tahmasebi S, et al. Among authors: khoutorsky a. Cell Stem Cell. 2014 May 1;14(5):606-16. doi: 10.1016/j.stem.2014.02.005. Epub 2014 Mar 13. Cell Stem Cell. 2014. PMID: 24630793 Free article.
Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia.
Verma V, Drury GL, Parisien M, Özdağ Acarli AN, Al-Aubodah TA, Nijnik A, Wen X, Tugarinov N, Verner M, Klares R 3rd, Linton A, Krock E, Morado Urbina CE, Winsvold B, Fritsche LG, Fors EA, Piccirillo C, Khoutorsky A, Svensson CI, Fitzcharles MA, Ingelmo PM, Bernard NF, Dupuy FP, Üçeyler N, Sommer C, King IL, Meloto CB, Diatchenko L; HUNT-All In Pain. Verma V, et al. Among authors: khoutorsky a. Pain. 2022 Jul 1;163(7):e821-e836. doi: 10.1097/j.pain.0000000000002498. Epub 2021 Sep 24. Pain. 2022. PMID: 34913882 Free PMC article.
Microglia-mediated degradation of perineuronal nets promotes pain.
Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister KC, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A. Tansley S, et al. Among authors: khoutorsky a. Science. 2022 Jul;377(6601):80-86. doi: 10.1126/science.abl6773. Epub 2022 May 26. Science. 2022. PMID: 35617374
Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice.
Roque PS, Thörn Perez C, Hooshmandi M, Wong C, Eslamizade MJ, Heshmati S, Brown N, Sharma V, Lister KC, Goyon VM, Neagu-Lund L, Shen C, Daccache N, Sato H, Sato T, Mogil JS, Nader K, Gkogkas CG, Iordanova MD, Prager-Khoutorsky M, McBride HM, Lacaille JC, Wykes L, Schricker T, Khoutorsky A. Roque PS, et al. Among authors: khoutorsky a. J Clin Invest. 2023 Jan 17;133(2):e159344. doi: 10.1172/JCI159344. J Clin Invest. 2023. PMID: 36394958 Free PMC article.
4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling.
Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG, Khoutorsky A. Wong C, et al. Among authors: khoutorsky a. Sci Adv. 2023 Nov 3;9(44):eadh9603. doi: 10.1126/sciadv.adh9603. Epub 2023 Nov 3. Sci Adv. 2023. PMID: 37922363 Free PMC article.
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. Melemedjian OK, et al. Among authors: khoutorsky a. Pain. 2013 Jul;154(7):1080-91. doi: 10.1016/j.pain.2013.03.021. Epub 2013 Mar 15. Pain. 2013. PMID: 23607966 Free PMC article.
Translational control of chronic pain.
Melemedjian OK, Khoutorsky A. Melemedjian OK, et al. Among authors: khoutorsky a. Prog Mol Biol Transl Sci. 2015;131:185-213. doi: 10.1016/bs.pmbts.2014.11.006. Epub 2015 Jan 30. Prog Mol Biol Transl Sci. 2015. PMID: 25744674 Review.
65 results