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Page 1
Reverse engineering synthetic antiviral amyloids.
Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerreiro P, Louros N, Kaptein SJF, Ibañez LI, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Rousseau F, Schymkowitz J. Michiels E, et al. Among authors: khodaparast l. Nat Commun. 2020 Jun 5;11(1):2832. doi: 10.1038/s41467-020-16721-8. Nat Commun. 2020. PMID: 32504029 Free PMC article.
De novo design of a biologically active amyloid.
Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KP, Serpell L, Schymkowitz J, Rousseau F. Gallardo R, et al. Among authors: khodaparast l. Science. 2016 Nov 11;354(6313):aah4949. doi: 10.1126/science.aah4949. Science. 2016. PMID: 27846578 Free article.
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.
Khodaparast L, Khodaparast L, Gallardo R, Louros NN, Michiels E, Ramakrishnan R, Ramakers M, Claes F, Young L, Shahrooei M, Wilkinson H, Desager M, Mengistu Tadesse W, Nilsson KPR, Hammarström P, Aertsen A, Carpentier S, Van Eldere J, Rousseau F, Schymkowitz J. Khodaparast L, et al. Nat Commun. 2018 Feb 28;9(1):866. doi: 10.1038/s41467-018-03131-0. Nat Commun. 2018. PMID: 29491361 Free PMC article.
Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention.
Khodaparast L, Wu G, Khodaparast L, Schmidt BZ, Rousseau F, Schymkowitz J. Khodaparast L, et al. Front Mol Biosci. 2021 Jun 2;8:681855. doi: 10.3389/fmolb.2021.681855. eCollection 2021. Front Mol Biosci. 2021. PMID: 34150852 Free PMC article. Review.
Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness.
Mortier J, Gayán E, Van Eyken R, Torres Montaguth OE, Khodaparast L, Khodaparast L, Houben B, Carpentier S, Rousseau F, Schymkowitz J, Aertsen A. Mortier J, et al. Among authors: khodaparast l. mBio. 2021 Aug 31;12(4):e0112921. doi: 10.1128/mBio.01129-21. Epub 2021 Jul 6. mBio. 2021. PMID: 34225482 Free PMC article.
Synthetic Pept-Ins as a Generic Amyloid-Like Aggregation-Based Platform for In Vivo PET Imaging of Intracellular Targets.
Siemons M, Luyten K, Khodaparast L, Khodaparast L, Lecina J, Claes F, Gallardo R, Koole M, Ramakers M, Schymkowitz J, Bormans G, Rousseau F. Siemons M, et al. Among authors: khodaparast l. Bioconjug Chem. 2021 Sep 15;32(9):2052-2064. doi: 10.1021/acs.bioconjchem.1c00369. Epub 2021 Sep 6. Bioconjug Chem. 2021. PMID: 34487434 Free PMC article.
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