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A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.
Mortlock S, Corona RI, Kho PF, Pharoah P, Seo JH, Freedman ML, Gayther SA, Siedhoff MT, Rogers PAW, Leuchter R, Walsh CS, Cass I, Karlan BY, Rimel BJ; Ovarian Cancer Association Consortium, International Endometriosis Genetics Consortium; Montgomery GW, Lawrenson K, Kar SP. Mortlock S, et al. Among authors: kho pf. Cell Rep Med. 2022 Mar 15;3(3):100542. doi: 10.1016/j.xcrm.2022.100542. eCollection 2022 Mar 15. Cell Rep Med. 2022. PMID: 35492879 Free PMC article.
Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
Kho PF, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Brinton L, Buchanan DD, Chanock SJ, Chen C, Chen MM, Cheng THT, Cook LS, Crous-Bous M, Czene K, De Vivo I, Dennis J, Dörk T, Dowdy SC, Dunning AM, Dürst M, Easton DF, Ekici AB, Fasching PA, Fridley BL, Friedenreich CM, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankinson SE, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hunter DJ, Jones A, Kraft P, Krakstad C, Lambrechts D, Le Marchand L, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Milne RL, Mints M, Nassir R, Otton G, Palles C, Pooler L, Proietto T, Rebbeck TR, Renner SP, Risch HA, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Tham E, Tomlinson I, Trovik J, Turman C, Tyrer JP, Van Den Berg D, Wang Z, Wentzensen N, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Webb PM, Thompson DJ, Spurdle AB, Glubb DM, O'Mara TA. Kho PF, et al. Int J Cancer. 2021 Jan 15;148(2):307-319. doi: 10.1002/ijc.33206. Epub 2020 Aug 7. Int J Cancer. 2021. PMID: 32851660 Free PMC article.
Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus.
Kho PF, Mortlock S; Endometrial Cancer Association Consortium; International Endometriosis Genetics Consortium; Rogers PAW, Nyholt DR, Montgomery GW, Spurdle AB, Glubb DM, O'Mara TA. Kho PF, et al. Hum Genet. 2021 Sep;140(9):1353-1365. doi: 10.1007/s00439-021-02312-0. Epub 2021 Jul 15. Hum Genet. 2021. PMID: 34268601
Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.
Campos AI, Ingold N, Huang Y, Mitchell BL, Kho PF, Han X, García-Marín LM, Ong JS; 23andMe Research Team; Law MH, Yokoyama JS, Martin NG, Dong X, Cuellar-Partida G, MacGregor S, Aslibekyan S, Rentería ME. Campos AI, et al. Among authors: kho pf. Sleep. 2023 Mar 9;46(3):zsac308. doi: 10.1093/sleep/zsac308. Sleep. 2023. PMID: 36525587 Free PMC article.
Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels.
Wang X, Kho PF, Ramachandran D, Bafligil C, Amant F, Goode EL, Scott RJ, Tomlinson I, Evans DG, Crosbie EJ, Dörk T, Spurdle AB, Glubb DM, O'Mara TA. Wang X, et al. Among authors: kho pf. iScience. 2023 Apr 7;26(5):106590. doi: 10.1016/j.isci.2023.106590. eCollection 2023 May 19. iScience. 2023. PMID: 37168552 Free PMC article.
24 results