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mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Mauger DM, et al. Among authors: khatwani n. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. doi: 10.1073/pnas.1908052116. Epub 2019 Nov 11. Proc Natl Acad Sci U S A. 2019. PMID: 31712433 Free PMC article.
Impact of mRNA chemistry and manufacturing process on innate immune activation.
Nelson J, Sorensen EW, Mintri S, Rabideau AE, Zheng W, Besin G, Khatwani N, Su SV, Miracco EJ, Issa WJ, Hoge S, Stanton MG, Joyal JL. Nelson J, et al. Among authors: khatwani n. Sci Adv. 2020 Jun 24;6(26):eaaz6893. doi: 10.1126/sciadv.aaz6893. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32637598 Free PMC article.
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs.
Hewitt SL, Bai A, Bailey D, Ichikawa K, Zielinski J, Karp R, Apte A, Arnold K, Zacharek SJ, Iliou MS, Bhatt K, Garnaas M, Musenge F, Davis A, Khatwani N, Su SV, MacLean G, Farlow SJ, Burke K, Frederick JP. Hewitt SL, et al. Among authors: khatwani n. Sci Transl Med. 2019 Jan 30;11(477):eaat9143. doi: 10.1126/scitranslmed.aat9143. Sci Transl Med. 2019. PMID: 30700577
Memory CD8+ T cell responses to cancer.
Han J, Khatwani N, Searles TG, Turk MJ, Angeles CV. Han J, et al. Among authors: khatwani n. Semin Immunol. 2020 Jun;49:101435. doi: 10.1016/j.smim.2020.101435. Epub 2020 Nov 30. Semin Immunol. 2020. PMID: 33272898 Free PMC article. Review.
Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ. Molodtsov AK, et al. Among authors: khatwani n. Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. Immunity. 2021. PMID: 34525340 Free PMC article.
A novel approach for oxidation analysis of therapeutic proteins.
Turyan I, Khatwani N, Sosic Z, Jayawickreme S, Mandler D. Turyan I, et al. Among authors: khatwani n. Anal Biochem. 2016 Feb 1;494:108-13. doi: 10.1016/j.ab.2015.10.015. Epub 2015 Nov 5. Anal Biochem. 2016. PMID: 26548959
16 results