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Novel slow-binding reversible acetylcholinesterase inhibitors based on uracil moieties for possible treatment of myasthenia gravis and protection from organophosphate poisoning.
Saifina LF, Abdalla M, Gubaidullina LM, Zueva IV, Eltayb WA, El-Arabey AA, Kharlamova AD, Lenina OA, Semenov VE, Petrov KA. Saifina LF, et al. Among authors: kharlamova ad. Eur J Med Chem. 2023 Jan 15;246:114949. doi: 10.1016/j.ejmech.2022.114949. Epub 2022 Nov 24. Eur J Med Chem. 2023. PMID: 36462442
6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.
Semenov VE, Zueva IV, Mukhamedyarov MA, Lushchekina SV, Kharlamova AD, Petukhova EO, Mikhailov AS, Podyachev SN, Saifina LF, Petrov KA, Minnekhanova OA, Zobov VV, Nikolsky EE, Masson P, Reznik VS. Semenov VE, et al. Among authors: kharlamova ad. ChemMedChem. 2015 Nov;10(11):1863-74. doi: 10.1002/cmdc.201500334. Epub 2015 Sep 28. ChemMedChem. 2015. PMID: 26412714