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Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.
Park SM, Miyamoto DK, Han GYQ, Chan M, Curnutt NM, Tran NL, Velleca A, Kim JH, Schurer A, Chang K, Xu W, Kharas MG, Woo CM. Park SM, et al. Among authors: kharas mg. Cancer Cell. 2023 Apr 10;41(4):726-739.e11. doi: 10.1016/j.ccell.2023.02.010. Epub 2023 Mar 9. Cancer Cell. 2023. PMID: 36898380 Free PMC article.
S6 kinase 2 potentiates interleukin-3-driven cell proliferation.
Cruz R, Hedden L, Boyer D, Kharas MG, Fruman DA, Lee-Fruman KK. Cruz R, et al. Among authors: kharas mg. J Leukoc Biol. 2005 Dec;78(6):1378-85. doi: 10.1189/jlb.0405225. Epub 2005 Oct 4. J Leukoc Biol. 2005. PMID: 16204634 Free PMC article.
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.
Mullally A, Lane SW, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, Paktinat M, Haydu JE, Housman E, Lord AM, Wernig G, Kharas MG, Mercher T, Kutok JL, Gilliland DG, Ebert BL. Mullally A, et al. Among authors: kharas mg. Cancer Cell. 2010 Jun 15;17(6):584-96. doi: 10.1016/j.ccr.2010.05.015. Cancer Cell. 2010. PMID: 20541703 Free PMC article.
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.
Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL. Miller PG, et al. Among authors: kharas mg. Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13. Cancer Cell. 2013. PMID: 23770013 Free PMC article.
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.
Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Park SM, et al. Among authors: kharas mg. J Exp Med. 2014 Jan 13;211(1):71-87. doi: 10.1084/jem.20130736. Epub 2014 Jan 6. J Exp Med. 2014. PMID: 24395885 Free PMC article.
Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein.
Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O'Reilly RJ, Liu C, Scheinberg DA. Veomett N, et al. Among authors: kharas mg. Clin Cancer Res. 2014 Aug 1;20(15):4036-46. doi: 10.1158/1078-0432.CCR-13-2756. Epub 2014 May 21. Clin Cancer Res. 2014. PMID: 24850840 Free PMC article.
Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.
Kotini AG, Chang CJ, Chow A, Yuan H, Ho TC, Wang T, Vora S, Solovyov A, Husser C, Olszewska M, Teruya-Feldstein J, Perumal D, Klimek VM, Spyridonidis A, Rampal RK, Silverman L, Reddy EP, Papaemmanuil E, Parekh S, Greenbaum BD, Leslie CS, Kharas MG, Papapetrou EP. Kotini AG, et al. Among authors: kharas mg. Cell Stem Cell. 2017 Mar 2;20(3):315-328.e7. doi: 10.1016/j.stem.2017.01.009. Epub 2017 Feb 16. Cell Stem Cell. 2017. PMID: 28215825 Free PMC article.
82 results