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SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern.
Hawman DW, Meade-White K, Archer J, Leventhal S, Wilson D, Shaia C, Randall S, Khandhar AP, Hsiang TY, Gale M Jr, Berglund P, Fuller DH, Feldmann H, Erasmus JH. Hawman DW, et al. Among authors: khandhar ap. bioRxiv [Preprint]. 2021 Dec 13:2021.12.10.472134. doi: 10.1101/2021.12.10.472134. bioRxiv. 2021. PMID: 34931189 Free PMC article. Updated. Preprint.
Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine.
MacMillen Z, Hatzakis K, Simpson A, Shears MJ, Watson F, Erasmus JH, Khandhar AP, Wilder B, Murphy SC, Reed SG, Davie JW, Avril M. MacMillen Z, et al. Among authors: khandhar ap. bioRxiv [Preprint]. 2023 May 23:2023.05.23.541932. doi: 10.1101/2023.05.23.541932. bioRxiv. 2023. PMID: 37292739 Free PMC article. Updated. Preprint.
A polyvalent RNA vaccine reduces the immune imprinting phenotype in mice and induces neutralizing antibodies against omicron SARS-CoV-2.
Costa Rocha VP, Souza Machado BA, Barreto BC, Quadros HC, Santana Fernandes AM, Lima EDS, Bandeira ME, Meira CS, Moraes Dos Santos Fonseca L, Erasmus J, Khandhar A, Berglund P, Reed S, José da Silva Badaró R, Pereira Soares MB. Costa Rocha VP, et al. Heliyon. 2024 Feb 6;10(4):e25539. doi: 10.1016/j.heliyon.2024.e25539. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38370238 Free PMC article.
A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned.
Oâ Connor MA, Hawman DW, Meade-White K, Leventhal S, Song W, Randall S, Archer J, Lewis TB, Brown B, Iwayama N, Ahrens C, Garrison W, Wangari S, Guerriero KA, Hanley P, Lovaglio J, Saturday G, Edlefsen PT, Khandhar A, Feldmann H, Fuller DH, Erasmus JH. Oâ Connor MA, et al. bioRxiv [Preprint]. 2022 Aug 9:2022.08.08.503239. doi: 10.1101/2022.08.08.503239. bioRxiv. 2022. PMID: 35982677 Free PMC article. Updated. Preprint.
A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation.
Kimura T, Leal JM, Simpson A, Warner NL, Berube BJ, Archer JF, Park S, Kurtz R, Hinkley T, Nicholes K, Sharma S, Duthie MS, Berglund P, Reed SG, Khandhar AP, Erasmus JH. Kimura T, et al. Among authors: khandhar ap. Mol Ther. 2023 Aug 2;31(8):2360-2375. doi: 10.1016/j.ymthe.2023.06.017. Epub 2023 Jul 3. Mol Ther. 2023. PMID: 37403357 Free article.
A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned.
O'Connor MA, Hawman DW, Meade-White K, Leventhal S, Song W, Randall S, Archer J, Lewis TB, Brown B, Fredericks MN, Sprouse KR, Tunggal HC, Maughan M, Iwayama N, Ahrens C, Garrison W, Wangari S, Guerriero KA, Hanley P, Lovaglio J, Saturday G, Veesler D, Edlefsen PT, Khandhar AP, Feldmann H, Fuller DH, Erasmus JH. O'Connor MA, et al. Among authors: khandhar ap. PLoS Pathog. 2023 Apr 19;19(4):e1011298. doi: 10.1371/journal.ppat.1011298. eCollection 2023 Apr. PLoS Pathog. 2023. PMID: 37075079 Free PMC article.
47 results