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Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease.
Haq S, Wang H, Grondin J, Banskota S, Marshall JK, Khan II, Chauhan U, Cote F, Kwon YH, Philpott D, Brumell JH, Surette M, Steinberg GR, Khan WI. Haq S, et al. Among authors: khan wi, khan ii. Sci Adv. 2021 Nov 5;7(45):eabi6442. doi: 10.1126/sciadv.abi6442. Epub 2021 Nov 5. Sci Adv. 2021. PMID: 34739317 Free PMC article.
Serotonin has a key role in pathogenesis of experimental colitis.
Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Côté F, Mallet J, Khan WI. Ghia JE, et al. Among authors: khan wi. Gastroenterology. 2009 Nov;137(5):1649-60. doi: 10.1053/j.gastro.2009.08.041. Epub 2009 Aug 23. Gastroenterology. 2009. PMID: 19706294
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR. Crane JD, et al. Among authors: khan wi. Nat Med. 2015 Feb;21(2):166-72. doi: 10.1038/nm.3766. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485911 Free PMC article.
101 results