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Novel approaches to whole sporozoite vaccination against malaria.
Bijker EM, Borrmann S, Kappe SH, Mordmüller B, Sack BK, Khan SM. Bijker EM, et al. Among authors: khan sm. Vaccine. 2015 Dec 22;33(52):7462-8. doi: 10.1016/j.vaccine.2015.09.095. Epub 2015 Oct 23. Vaccine. 2015. PMID: 26469716 Free PMC article. Review.
Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes.
van Schaijk BC, Kumar TR, Vos MW, Richman A, van Gemert GJ, Li T, Eappen AG, Williamson KC, Morahan BJ, Fishbaugher M, Kennedy M, Camargo N, Khan SM, Janse CJ, Sim KL, Hoffman SL, Kappe SH, Sauerwein RW, Fidock DA, Vaughan AM. van Schaijk BC, et al. Among authors: khan sm. Eukaryot Cell. 2014 May;13(5):550-9. doi: 10.1128/EC.00264-13. Epub 2013 Dec 2. Eukaryot Cell. 2014. PMID: 24297444 Free PMC article.
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H. Triller G, et al. Among authors: khan sm. Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.007. Epub 2017 Nov 29. Immunity. 2017. PMID: 29195810 Free PMC article.
Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates.
Annoura T, Ploemen IH, van Schaijk BC, Sajid M, Vos MW, van Gemert GJ, Chevalley-Maurel S, Franke-Fayard BM, Hermsen CC, Gego A, Franetich JF, Mazier D, Hoffman SL, Janse CJ, Sauerwein RW, Khan SM. Annoura T, et al. Among authors: khan sm. Vaccine. 2012 Mar 30;30(16):2662-70. doi: 10.1016/j.vaccine.2012.02.010. Epub 2012 Feb 16. Vaccine. 2012. PMID: 22342550
A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1.
Roestenberg M, Walk J, van der Boor SC, Langenberg MCC, Hoogerwerf MA, Janse JJ, Manurung M, Yap XZ, García AF, Koopman JPR, Meij P, Wessels E, Teelen K, van Waardenburg YM, van de Vegte-Bolmer M, van Gemert GJ, Visser LG, van der Ven AJAM, de Mast Q, Natasha KC, Abebe Y, Murshedkar T, Billingsley PF, Richie TL, Sim BKL, Janse CJ, Hoffman SL, Khan SM, Sauerwein RW. Roestenberg M, et al. Among authors: khan sm. Sci Transl Med. 2020 May 20;12(544):eaaz5629. doi: 10.1126/scitranslmed.aaz5629. Sci Transl Med. 2020. PMID: 32434847 Clinical Trial.
A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites.
van Schaijk BC, Ploemen IH, Annoura T, Vos MW, Foquet L, van Gemert GJ, Chevalley-Maurel S, van de Vegte-Bolmer M, Sajid M, Franetich JF, Lorthiois A, Leroux-Roels G, Meuleman P, Hermsen CC, Mazier D, Hoffman SL, Janse CJ, Khan SM, Sauerwein RW. van Schaijk BC, et al. Among authors: khan sm. Elife. 2014 Nov 19;3:e03582. doi: 10.7554/eLife.03582. Elife. 2014. PMID: 25407681 Free PMC article.
Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.
Lasonder E, Janse CJ, van Gemert GJ, Mair GR, Vermunt AM, Douradinha BG, van Noort V, Huynen MA, Luty AJ, Kroeze H, Khan SM, Sauerwein RW, Waters AP, Mann M, Stunnenberg HG. Lasonder E, et al. Among authors: khan sm. PLoS Pathog. 2008 Oct;4(10):e1000195. doi: 10.1371/journal.ppat.1000195. Epub 2008 Oct 31. PLoS Pathog. 2008. PMID: 18974882 Free PMC article.
The use of transgenic parasites in malaria vaccine research.
Othman AS, Marin-Mogollon C, Salman AM, Franke-Fayard BM, Janse CJ, Khan SM. Othman AS, et al. Among authors: khan sm. Expert Rev Vaccines. 2017 Jul;16(7):1-13. doi: 10.1080/14760584.2017.1333426. Epub 2017 May 30. Expert Rev Vaccines. 2017. PMID: 28525963 Review.
521 results