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Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler.
Firsov AM, Khailova LS, Rokitskaya TI, Kotova EA, Antonenko YN. Firsov AM, et al. Among authors: khailova ls. Biochemistry (Mosc). 2022 Aug;87(8):812-822. doi: 10.1134/S0006297922080120. Biochemistry (Mosc). 2022. PMID: 36171648
Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondria.
Antonenko YN, Khailova LS, Knorre DA, Markova OV, Rokitskaya TI, Ilyasova TM, Severina II, Kotova EA, Karavaeva YE, Prikhodko AS, Severin FF, Skulachev VP. Antonenko YN, et al. Among authors: khailova ls. PLoS One. 2013 Apr 23;8(4):e61902. doi: 10.1371/journal.pone.0061902. Print 2013. PLoS One. 2013. PMID: 23626747 Free PMC article.
Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria.
Denisov SS, Kotova EA, Khailova LS, Korshunova GA, Antonenko YN. Denisov SS, et al. Among authors: khailova ls. Bioelectrochemistry. 2014 Aug;98:30-8. doi: 10.1016/j.bioelechem.2014.02.002. Epub 2014 Mar 5. Bioelectrochemistry. 2014. PMID: 24650997
A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.
Khailova LS, Silachev DN, Rokitskaya TI, Avetisyan AV, Lyamsaev KG, Severina II, Il'yasova TM, Gulyaev MV, Dedukhova VI, Trendeleva TA, Plotnikov EY, Zvyagilskaya RA, Chernyak BV, Zorov DB, Antonenko YN, Skulachev VP. Khailova LS, et al. Biochim Biophys Acta. 2014 Oct;1837(10):1739-47. doi: 10.1016/j.bbabio.2014.07.006. Epub 2014 Jul 16. Biochim Biophys Acta. 2014. PMID: 25038514 Free article.
A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector.
Antonenko YN, Denisov SS, Silachev DN, Khailova LS, Jankauskas SS, Rokitskaya TI, Danilina TI, Kotova EA, Korshunova GA, Plotnikov EY, Zorov DB. Antonenko YN, et al. Among authors: khailova ls. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2463-2473. doi: 10.1016/j.bbagen.2016.07.014. Epub 2016 Jul 20. Biochim Biophys Acta. 2016. PMID: 27450891
Alkyl-substituted phenylamino derivatives of 7-nitrobenz-2-oxa-1,3-diazole as uncouplers of oxidative phosphorylation and antibacterial agents: involvement of membrane proteins in the uncoupling action.
Antonenko YN, Denisov SS, Khailova LS, Nazarov PA, Rokitskaya T, Tashlitsky VN, Firsov AM, Korshunova GA, Kotova EA. Antonenko YN, et al. Among authors: khailova ls. Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):377-387. doi: 10.1016/j.bbamem.2016.12.014. Epub 2016 Dec 21. Biochim Biophys Acta Biomembr. 2017. PMID: 28011176 Free article.
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