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Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes.
Žuna K, Jovanović O, Khailova LS, Škulj S, Brkljača Z, Kreiter J, Kotova EA, Vazdar M, Antonenko YN, Pohl EE. Žuna K, et al. Among authors: khailova ls. Biomolecules. 2021 Aug 9;11(8):1178. doi: 10.3390/biom11081178. Biomolecules. 2021. PMID: 34439844 Free PMC article.
Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondria.
Antonenko YN, Khailova LS, Knorre DA, Markova OV, Rokitskaya TI, Ilyasova TM, Severina II, Kotova EA, Karavaeva YE, Prikhodko AS, Severin FF, Skulachev VP. Antonenko YN, et al. Among authors: khailova ls. PLoS One. 2013 Apr 23;8(4):e61902. doi: 10.1371/journal.pone.0061902. Print 2013. PLoS One. 2013. PMID: 23626747 Free PMC article.
Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria.
Denisov SS, Kotova EA, Khailova LS, Korshunova GA, Antonenko YN. Denisov SS, et al. Among authors: khailova ls. Bioelectrochemistry. 2014 Aug;98:30-8. doi: 10.1016/j.bioelechem.2014.02.002. Epub 2014 Mar 5. Bioelectrochemistry. 2014. PMID: 24650997
Alkyl esters of 7-hydroxycoumarin-3-carboxylic acid as potent tissue-specific uncouplers of oxidative phosphorylation: Involvement of ATP/ADP translocase in mitochondrial uncoupling.
Krasnov VS, Kirsanov RS, Khailova LS, Popova LB, Lyamzaev KG, Firsov AM, Korshunova GA, Kotova EA, Antonenko YN. Krasnov VS, et al. Among authors: khailova ls. Arch Biochem Biophys. 2022 Oct 15;728:109366. doi: 10.1016/j.abb.2022.109366. Epub 2022 Jul 22. Arch Biochem Biophys. 2022. PMID: 35878680
Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler.
Firsov AM, Khailova LS, Rokitskaya TI, Kotova EA, Antonenko YN. Firsov AM, et al. Among authors: khailova ls. Biochemistry (Mosc). 2022 Aug;87(8):812-822. doi: 10.1134/S0006297922080120. Biochemistry (Mosc). 2022. PMID: 36171648
74 results