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Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake.
Br J Clin Pharmacol. 2020 Dec;86(12):2362-2376. doi: 10.1111/bcp.14334. Epub 2020 Jun 10.
Br J Clin Pharmacol. 2020.
PMID: 32358822
Free PMC article.
Exposure-response relationship of regorafenib efficacy in patients with hepatocellular carcinoma.
Solms A, Reinecke I, Fiala-Buskies S, Keunecke A, Drenth HJ, Bruix J, Meinhardt G, Cleton A, Ploeger B.
Solms A, et al. Among authors: keunecke a.
Eur J Pharm Sci. 2017 Nov 15;109S:S149-S153. doi: 10.1016/j.ejps.2017.05.050. Epub 2017 May 23.
Eur J Pharm Sci. 2017.
PMID: 28549676
Free article.
Clinical Trial.
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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach.
Betts A, Keunecke A, van Steeg TJ, van der Graaf PH, Avery LB, Jones H, Berkhout J.
Betts A, et al. Among authors: keunecke a.
MAbs. 2018 Jul;10(5):751-764. doi: 10.1080/19420862.2018.1462429. Epub 2018 May 14.
MAbs. 2018.
PMID: 29634430
Free PMC article.
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Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension.
Willmann S, Keller AK, Meyer M, van der Mey D, Wirsching G, Zhang Y, Drenth HJ, Keunecke A, Vendel E, Saleh S.
Willmann S, et al. Among authors: keunecke a.
Pediatr Pulmonol. 2023 Mar;58(3):908-917. doi: 10.1002/ppul.26277. Epub 2022 Dec 28.
Pediatr Pulmonol. 2023.
PMID: 36507572
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White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.
Vlasakakis G, Comets E, Keunecke A, Gueorguieva I, Magni P, Terranova N, Della Pasqua O, de Lange EC, Kloft C.
Vlasakakis G, et al. Among authors: keunecke a.
CPT Pharmacometrics Syst Pharmacol. 2013 May 1;2(5):e40. doi: 10.1038/psp.2013.16.
CPT Pharmacometrics Syst Pharmacol. 2013.
PMID: 23887723
Free PMC article.
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