Kettenberger H - Search Results

1

Ocular Pharmacokinetics of Intravitreally Injected Protein Therapeutics: Comparison among Standard-of-Care Formats.

Jakubiak P, Alvarez-Sánchez R, Fueth M, Broders O, Kettenberger H, Stubenrauch K, Caruso A. Jakubiak P, et al. Among authors: kettenberger h. Mol Pharm. 2021 Jun 7;18(6):2208-2217. doi: 10.1021/acs.molpharmaceut.0c01218. Epub 2021 May 20. Mol Pharm. 2021. PMID: 34014104

2

Impact of molecular processing in the hinge region of therapeutic IgG4 antibodies on disposition profiles in cynomolgus monkeys.

Stubenrauch K, Wessels U, Regula JT, Kettenberger H, Schleypen J, Kohnert U. Stubenrauch K, et al. Among authors: kettenberger h. Drug Metab Dispos. 2010 Jan;38(1):84-91. doi: 10.1124/dmd.109.029751. Drug Metab Dispos. 2010. PMID: 19850673

3

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies.

Schaefer W, Regula JT, Bähner M, Schanzer J, Croasdale R, Dürr H, Gassner C, Georges G, Kettenberger H, Imhof-Jung S, Schwaiger M, Stubenrauch KG, Sustmann C, Thomas M, Scheuer W, Klein C. Schaefer W, et al. Among authors: kettenberger h. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11187-92. doi: 10.1073/pnas.1019002108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690412 Free PMC article.

4

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

Klein C, Sustmann C, Thomas M, Stubenrauch K, Croasdale R, Schanzer J, Brinkmann U, Kettenberger H, Regula JT, Schaefer W. Klein C, et al. Among authors: kettenberger h. MAbs. 2012 Nov-Dec;4(6):653-63. doi: 10.4161/mabs.21379. Epub 2012 Aug 27. MAbs. 2012. PMID: 22925968 Free PMC article. Review.

5

Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction.

Caruso A, Füth M, Alvarez-Sánchez R, Belli S, Diack C, Maass KF, Schwab D, Kettenberger H, Mazer NA. Caruso A, et al. Among authors: kettenberger h. Mol Pharm. 2020 Feb 3;17(2):695-709. doi: 10.1021/acs.molpharmaceut.9b01191. Epub 2020 Jan 16. Mol Pharm. 2020. PMID: 31876425

6

Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry.

Jensen PF, Larraillet V, Schlothauer T, Kettenberger H, Hilger M, Rand KD. Jensen PF, et al. Among authors: kettenberger h. Mol Cell Proteomics. 2015 Jan;14(1):148-61. doi: 10.1074/mcp.M114.042044. Epub 2014 Nov 6. Mol Cell Proteomics. 2015. PMID: 25378534 Free PMC article.

7

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

Schoch A, Kettenberger H, Mundigl O, Winter G, Engert J, Heinrich J, Emrich T. Schoch A, et al. Among authors: kettenberger h. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5997-6002. doi: 10.1073/pnas.1408766112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918417 Free PMC article.

8

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villaseñor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C. Schadt S, et al. Among authors: kettenberger h. Drug Metab Dispos. 2019 Dec;47(12):1443-1456. doi: 10.1124/dmd.119.088997. Drug Metab Dispos. 2019. PMID: 31748266

9

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.

Beckmann R, Jensen K, Fenn S, Speck J, Krause K, Meier A, Röth M, Fauser S, Kimbung R, Logan DT, Steegmaier M, Kettenberger H. Beckmann R, et al. Among authors: kettenberger h. Nat Commun. 2021 Jan 29;12(1):708. doi: 10.1038/s41467-021-20949-3. Nat Commun. 2021. PMID: 33514724 Free PMC article.

10

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats.

Fernández-Quintero ML, Quoika PK, Wedl FS, Seidler CA, Kroell KB, Loeffler JR, Pomarici ND, Hoerschinger VJ, Bujotzek A, Georges G, Kettenberger H, Liedl KR. Fernández-Quintero ML, et al. Among authors: kettenberger h. Front Mol Biosci. 2022 Jan 26;9:812750. doi: 10.3389/fmolb.2022.812750. eCollection 2022. Front Mol Biosci. 2022. PMID: 35155578 Free PMC article.

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