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Page 1
A candidate antibody drug for prevention of malaria.
Williams KL, Guerrero S, Flores-Garcia Y, Kim D, Williamson KS, Siska C, Smidt P, Jepson SZ, Li K, Dennison SM, Mathis-Torres S, Chen X, Wille-Reece U, MacGill RS, Walker M, Jongert E, King CR, Ockenhouse C, Glanville J, Moon JE, Regules JA, Tan YC, Cavet G, Lippow SM, Robinson WH, Dutta S, Tomaras GD, Zavala F, Ketchem RR, Emerling DE. Williams KL, et al. Among authors: ketchem rr. Nat Med. 2024 Jan;30(1):117-129. doi: 10.1038/s41591-023-02659-z. Epub 2024 Jan 2. Nat Med. 2024. PMID: 38167935 Free PMC article.
Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity.
Kerwin BA, Bennett C, Brodsky Y, Clark R, Floyd JA, Gillespie A, Mayer BT, McClure M, Siska C, Seaman MS, Seaton KE, Shaver J, Tomaras GD, Yates NL, Ketchem RR. Kerwin BA, et al. Among authors: ketchem rr. J Pharm Sci. 2020 Jan;109(1):233-246. doi: 10.1016/j.xphs.2019.07.009. Epub 2019 Jul 23. J Pharm Sci. 2020. PMID: 31348937 Free PMC article.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Henne KR, Ason B, Howard M, Wang W, Sun J, Higbee J, Tang J, Matsuda KC, Xu R, Zhou L, Chan JC, King C, Piper DE, Ketchem RR, Michaels ML, Jackson SM, Retter MW. Henne KR, et al. Among authors: ketchem rr. J Pharmacol Exp Ther. 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4. J Pharmacol Exp Ther. 2015. PMID: 25653417
ADAM8 as a drug target in pancreatic cancer.
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW. Schlomann U, et al. Among authors: ketchem rr. Nat Commun. 2015 Jan 28;6:6175. doi: 10.1038/ncomms7175. Nat Commun. 2015. PMID: 25629724 Free PMC article.
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
Smith D, Helgason H, Sulem P, Bjornsdottir US, Lim AC, Sveinbjornsson G, Hasegawa H, Brown M, Ketchem RR, Gavala M, Garrett L, Jonasdottir A, Jonasdottir A, Sigurdsson A, Magnusson OT, Eyjolfsson GI, Olafsson I, Onundarson PT, Sigurdardottir O, Gislason D, Gislason T, Ludviksson BR, Ludviksdottir D, Boezen HM, Heinzmann A, Krueger M, Porsbjerg C, Ahluwalia TS, Waage J, Backer V, Deichmann KA, Koppelman GH, Bønnelykke K, Bisgaard H, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Johnston JA, Jonsdottir I, Stefansson K. Smith D, et al. Among authors: ketchem rr. PLoS Genet. 2017 Mar 8;13(3):e1006659. doi: 10.1371/journal.pgen.1006659. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28273074 Free PMC article.
Entanglement model of antibody viscosity.
Schmit JD, He F, Mishra S, Ketchem RR, Woods CE, Kerwin BA. Schmit JD, et al. Among authors: ketchem rr. J Phys Chem B. 2014 May 15;118(19):5044-9. doi: 10.1021/jp500434b. Epub 2014 May 2. J Phys Chem B. 2014. PMID: 24758234
29 results