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Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2302485120. doi: 10.1073/pnas.2302485120. Epub 2023 Jul 3.
Proc Natl Acad Sci U S A. 2023.
PMID: 37399416
Free PMC article.
Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.
Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng KW, Rhett JM, Spencer-Smith R, Hobbs GA, Camp ER, Koide S, O'Bryan JP.
Khan I, et al. Among authors: ketavarapu g.
Cell Rep. 2022 Feb 8;38(6):110322. doi: 10.1016/j.celrep.2022.110322.
Cell Rep. 2022.
PMID: 35139380
Free PMC article.
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Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.
Wallon L, Khan I, Teng KW, Koide A, Zuberi M, Li J, Ketavarapu G, Traaseth NJ, O'Bryan JP, Koide S.
Wallon L, et al. Among authors: ketavarapu g.
Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2204481119. doi: 10.1073/pnas.2204481119. Epub 2022 Oct 17.
Proc Natl Acad Sci U S A. 2022.
PMID: 36252024
Free PMC article.
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Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
Sha F, Kurosawa K, Glasser E, Ketavarapu G, Albazzaz S, Koide A, Koide S.
Sha F, et al. Among authors: ketavarapu g.
J Mol Biol. 2023 Apr 15;435(8):168010. doi: 10.1016/j.jmb.2023.168010. Epub 2023 Feb 16.
J Mol Biol. 2023.
PMID: 36806475
Free PMC article.
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Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ.
Oury J, et al. Among authors: ketavarapu g.
Nature. 2021 Jul;595(7867):404-408. doi: 10.1038/s41586-021-03672-3. Epub 2021 Jun 23.
Nature. 2021.
PMID: 34163073
Free PMC article.
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High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia.
Romero LA, Hattori T, Ali MAE, Ketavarapu G, Koide A, Park CY, Koide S.
Romero LA, et al. Among authors: ketavarapu g.
J Mol Biol. 2022 Mar 15;434(5):167402. doi: 10.1016/j.jmb.2021.167402. Epub 2021 Dec 24.
J Mol Biol. 2022.
PMID: 34958778
Free PMC article.
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Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications.
Albert C, Bracaglia L, Koide A, DiRito J, Lysyy T, Harkins L, Edwards C, Richfield O, Grundler J, Zhou K, Denbaum E, Ketavarapu G, Hattori T, Perincheri S, Langford J, Feizi A, Haakinson D, Hosgood SA, Nicholson ML, Pober JS, Saltzman WM, Koide S, Tietjen GT.
Albert C, et al. Among authors: ketavarapu g.
Nat Commun. 2022 Oct 11;13(1):5998. doi: 10.1038/s41467-022-33490-8.
Nat Commun. 2022.
PMID: 36220817
Free PMC article.
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