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The cytokine interleukin-11 crucially links bone formation, remodeling and resorption.
Cytokine Growth Factor Rev. 2021 Aug;60:18-27. doi: 10.1016/j.cytogfr.2021.04.002. Epub 2021 Apr 24.
Cytokine Growth Factor Rev. 2021.
PMID: 33940443
Review.
The role of proteolysis in interleukin-11 signaling.
Lokau J, Kespohl B, Kirschke S, Garbers C.
Lokau J, et al. Among authors: kespohl b.
Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119135. doi: 10.1016/j.bbamcr.2021.119135. Epub 2021 Oct 6.
Biochim Biophys Acta Mol Cell Res. 2022.
PMID: 34624437
Free article.
Review.
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Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.
Agthe M, et al. Among authors: kespohl b.
Cell Rep. 2018 Oct 2;25(1):10-18.e5. doi: 10.1016/j.celrep.2018.09.005.
Cell Rep. 2018.
PMID: 30282020
Free article.
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Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling.
Koch L, Kespohl B, Agthe M, Schumertl T, Düsterhöft S, Lemberg MK, Lokau J, Garbers C.
Koch L, et al. Among authors: kespohl b.
FASEB J. 2021 Mar;35(3):e21380. doi: 10.1096/fj.202002087R.
FASEB J. 2021.
PMID: 33566379
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Interleukin-6 controls recycling and degradation, but not internalization of its receptors.
Flynn CM, Kespohl B, Daunke T, Garbers Y, Düsterhöft S, Rose-John S, Haybaeck J, Lokau J, Aparicio-Siegmund S, Garbers C.
Flynn CM, et al. Among authors: kespohl b.
J Biol Chem. 2021 Jan-Jun;296:100434. doi: 10.1016/j.jbc.2021.100434. Epub 2021 Feb 19.
J Biol Chem. 2021.
PMID: 33610555
Free PMC article.
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Molecular characterization of the craniosynostosis-associated interleukin-11 receptor variants p.T306_S308dup and p.E364_V368del.
Kespohl B, Hegele AL, Düsterhöft S, Bakker H, Buettner FFR, Hartig R, Lokau J, Garbers C.
Kespohl B, et al.
FEBS J. 2024 Apr;291(8):1667-1683. doi: 10.1111/febs.17015. Epub 2023 Dec 7.
FEBS J. 2024.
PMID: 37994264
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The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans.
Ahmad I, Lokau J, Kespohl B, Malik NA, Baig SM, Hartig R, Behme D, Schwab R, Altmüller J, Jameel M, Mucha S, Thiele H, Tariq M, Nürnberg P, Erdmann J, Garbers C.
Ahmad I, et al. Among authors: kespohl b.
Sci Rep. 2023 Aug 18;13(1):13479. doi: 10.1038/s41598-023-39466-y.
Sci Rep. 2023.
PMID: 37596289
Free PMC article.
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Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling.
Kespohl B, Hartig R, Garbers Y, Lokau J, Garbers C.
Kespohl B, et al.
Genes Dis. 2022 May 16;10(2):373-376. doi: 10.1016/j.gendis.2022.05.001. eCollection 2023 Mar.
Genes Dis. 2022.
PMID: 37223536
Free PMC article.
No abstract available.
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