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How the COVID-19 pandemic highlights the necessity of animal research.
Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens MJAG, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer JA, Kersten S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman WJH, Korosi A, Krugers HJ, Kuiken T, Kushner SA, Langermans JAM, Lesscher HMB, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pollux BJA, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries TJ, de Vrij F, van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR. Genzel L, et al. Among authors: kersten s. Curr Biol. 2020 Sep 21;30(18):R1014-R1018. doi: 10.1016/j.cub.2020.08.030. Epub 2020 Aug 10. Curr Biol. 2020. PMID: 32961149 Free PMC article.
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake.
Lichtenstein L, Berbée JF, van Dijk SJ, van Dijk KW, Bensadoun A, Kema IP, Voshol PJ, Müller M, Rensen PC, Kersten S. Lichtenstein L, et al. Among authors: kersten s. Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7. doi: 10.1161/ATVBAHA.107.151894. Epub 2007 Aug 30. Arterioscler Thromb Vasc Biol. 2007. PMID: 17761937 Free article.
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans A, Kersten S, Müller M, van den Berg WB, van Rooijen N, Wabitsch M, Kullberg BJ, van der Meer JW, Kanneganti T, Tack CJ, Netea MG. Stienstra R, et al. Among authors: kersten s. Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016/j.cmet.2010.11.011. Cell Metab. 2010. PMID: 21109192 Free PMC article.
Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.
van Diepen JA, Stienstra R, Vroegrijk IO, van den Berg SA, Salvatori D, Hooiveld GJ, Kersten S, Tack CJ, Netea MG, Smit JW, Joosten LA, Havekes LM, van Dijk KW, Rensen PC. van Diepen JA, et al. Among authors: kersten s. J Lipid Res. 2013 Feb;54(2):448-56. doi: 10.1194/jlr.M031963. Epub 2012 Nov 17. J Lipid Res. 2013. PMID: 23160218 Free PMC article.
Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion.
Mattijssen F, Alex S, Swarts HJ, Groen AK, van Schothorst EM, Kersten S. Mattijssen F, et al. Among authors: kersten s. Mol Metab. 2013 Nov 20;3(2):135-44. doi: 10.1016/j.molmet.2013.11.004. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634819 Free PMC article.
Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.
Khedoe PP, Hoeke G, Kooijman S, Dijk W, Buijs JT, Kersten S, Havekes LM, Hiemstra PS, Berbée JF, Boon MR, Rensen PC. Khedoe PP, et al. Among authors: kersten s. J Lipid Res. 2015 Jan;56(1):51-9. doi: 10.1194/jlr.M052746. Epub 2014 Oct 28. J Lipid Res. 2015. PMID: 25351615 Free PMC article.
Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes.
Jonker JT, Smit JW, Hammer S, Snel M, van der Meer RW, Lamb HJ, Mattijssen F, Mudde K, Jazet IM, Dekkers OM, de Roos A, Romijn JA, Kersten S, Rensen PC. Jonker JT, et al. Among authors: kersten s. Am J Clin Nutr. 2013 Feb;97(2):255-60. doi: 10.3945/ajcn.112.043687. Epub 2013 Jan 2. Am J Clin Nutr. 2013. PMID: 23283507 Free article.
Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development.
Georgiadi A, Wang Y, Stienstra R, Tjeerdema N, Janssen A, Stalenhoef A, van der Vliet JA, de Roos A, Tamsma JT, Smit JW, Tan NS, Müller M, Rensen PC, Kersten S. Georgiadi A, et al. Among authors: kersten s. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1529-37. doi: 10.1161/ATVBAHA.113.301698. Epub 2013 May 2. Arterioscler Thromb Vasc Biol. 2013. PMID: 23640487
PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.
van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Hooiveld GJ, Rommelaere S, Galland F, Naquet P, Rutjes FP, Mensink RP, Schrauwen P, Tack CJ, Netea MG, Kersten S, Schalkwijk J, Stienstra R. van Diepen JA, et al. Among authors: kersten s. J Hepatol. 2014 Aug;61(2):366-72. doi: 10.1016/j.jhep.2014.04.013. Epub 2014 Apr 18. J Hepatol. 2014. PMID: 24751833
665 results