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Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue.
Ruppert PMM, Michielsen CCJR, Hazebroek EJ, Pirayesh A, Olivecrona G, Afman LA, Kersten S. Ruppert PMM, et al. Among authors: kersten s. Mol Metab. 2020 Oct;40:101033. doi: 10.1016/j.molmet.2020.101033. Epub 2020 Jun 3. Mol Metab. 2020. PMID: 32504883 Free PMC article. Clinical Trial.
The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment.
Mandard S, Zandbergen F, Tan NS, Escher P, Patsouris D, Koenig W, Kleemann R, Bakker A, Veenman F, Wahli W, Müller M, Kersten S. Mandard S, et al. Among authors: kersten s. J Biol Chem. 2004 Aug 13;279(33):34411-20. doi: 10.1074/jbc.M403058200. Epub 2004 Jun 9. J Biol Chem. 2004. PMID: 15190076 Free article.
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake.
Lichtenstein L, Berbée JF, van Dijk SJ, van Dijk KW, Bensadoun A, Kema IP, Voshol PJ, Müller M, Rensen PC, Kersten S. Lichtenstein L, et al. Among authors: kersten s. Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7. doi: 10.1161/ATVBAHA.107.151894. Epub 2007 Aug 30. Arterioscler Thromb Vasc Biol. 2007. PMID: 17761937 Free article.
Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages.
Lichtenstein L, Mattijssen F, de Wit NJ, Georgiadi A, Hooiveld GJ, van der Meer R, He Y, Qi L, Köster A, Tamsma JT, Tan NS, Müller M, Kersten S. Lichtenstein L, et al. Among authors: kersten s. Cell Metab. 2010 Dec 1;12(6):580-92. doi: 10.1016/j.cmet.2010.11.002. Cell Metab. 2010. PMID: 21109191 Free PMC article.
Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury.
Li S, Nagothu K, Ranganathan G, Ali SM, Shank B, Gokden N, Ayyadevara S, Megyesi J, Olivecrona G, Chugh SS, Kersten S, Portilla D. Li S, et al. Among authors: kersten s. Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F437-48. doi: 10.1152/ajprenal.00111.2012. Epub 2012 May 23. Am J Physiol Renal Physiol. 2012. PMID: 22622461 Free PMC article.
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ.
Alex S, Lange K, Amolo T, Grinstead JS, Haakonsson AK, Szalowska E, Koppen A, Mudde K, Haenen D, Al-Lahham S, Roelofsen H, Houtman R, van der Burg B, Mandrup S, Bonvin AM, Kalkhoven E, Müller M, Hooiveld GJ, Kersten S. Alex S, et al. Among authors: kersten s. Mol Cell Biol. 2013 Apr;33(7):1303-16. doi: 10.1128/MCB.00858-12. Epub 2013 Jan 22. Mol Cell Biol. 2013. PMID: 23339868 Free PMC article.
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