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Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease.
Rudilosso S, Stringer MS, Thrippleton M, Chappell F, Blair GW, Jaime Garcia D, Doubal F, Hamilton I, Janssen E, Kopczak A, Ingrisch M, Kerkhofs D, Backes WH, Staals J, Duering M, Dichgans M, Wardlaw JM; SVDs@target consortium. Rudilosso S, et al. Among authors: kerkhofs d. J Cereb Blood Flow Metab. 2023 Sep;43(9):1490-1502. doi: 10.1177/0271678X231173444. Epub 2023 May 3. J Cereb Blood Flow Metab. 2023. PMID: 37132279 Free PMC article.
Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease.
Rudilosso S, Chui E, Stringer MS, Thrippleton M, Chappell F, Blair GW, Garcia DJ, Doubal F, Hamilton I, Kopczak A, Ingrisch M, Kerkhofs D, Backes WH, Staals J, van Oostenbrugge R, Duering M, Dichgans M, Wardlaw JM; SVDs@Target Investigators. Rudilosso S, et al. Among authors: kerkhofs d. Neurology. 2022 Aug 1;99(5):e440-e452. doi: 10.1212/WNL.0000000000200614. Neurology. 2022. PMID: 35606147 Free PMC article.
Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.
Blair GW, Stringer MS, Thrippleton MJ, Chappell FM, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Kopczak A, Duering M, Ingrisch M, Kerkhofs D, Staals J, van den Brink H, Arts T, Backes WH, van Oostenbrugge R, Biessels GJ, Dichgans M, Wardlaw JM. Blair GW, et al. Among authors: kerkhofs d. Cereb Circ Cogn Behav. 2021 Jun 26;2:100020. doi: 10.1016/j.cccb.2021.100020. eCollection 2021. Cereb Circ Cogn Behav. 2021. PMID: 36324725 Free PMC article.
The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial.
Kopczak A, S Stringer M, van den Brink H, Kerkhofs D, W Blair G, van Dinther M, Onkenhout L, A Wartolowska K, Thrippleton MJ, Duering M, Staals J, Middeke M, André E, Norrving B, Bousser MG, Mansmann U, Rothwell PM, N Doubal F, van Oostenbrugge R, Biessels GJ, Webb AJ, Wardlaw JM, Dichgans M. Kopczak A, et al. Among authors: kerkhofs d. Eur Stroke J. 2023 Mar;8(1):387-397. doi: 10.1177/23969873221143570. Epub 2022 Dec 16. Eur Stroke J. 2023. PMID: 37021189 Free PMC article.
Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, Wartolowska KA, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators. Kopczak A, et al. Among authors: kerkhofs d. Lancet Neurol. 2023 Nov;22(11):991-1004. doi: 10.1016/S1474-4422(23)00293-4. Lancet Neurol. 2023. PMID: 37863608 Clinical Trial.
Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.
Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ, Foulquier S. Kerkhofs D, et al. Theranostics. 2020 Jul 25;10(21):9512-9527. doi: 10.7150/thno.44394. eCollection 2020. Theranostics. 2020. PMID: 32863942 Free PMC article.