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Transient proteolytic modification of mesenchymal stromal cells increases lung clearance rate and targeting to injured tissue.
Kerkelä E, Hakkarainen T, Mäkelä T, Raki M, Kambur O, Kilpinen L, Nikkilä J, Lehtonen S, Ritamo I, Pernu R, Pietilä M, Takalo R, Juvonen T, Bergström K, Kalso E, Valmu L, Laitinen S, Lehenkari P, Nystedt J. Kerkelä E, et al. Stem Cells Transl Med. 2013 Jul;2(7):510-20. doi: 10.5966/sctm.2012-0187. Epub 2013 Jun 3. Stem Cells Transl Med. 2013. PMID: 23734061 Free PMC article.
Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.
Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J. Mitkari B, et al. Among authors: kerkela e. Behav Brain Res. 2014 Feb 1;259:50-9. doi: 10.1016/j.bbr.2013.10.030. Epub 2013 Oct 29. Behav Brain Res. 2014. PMID: 24177208
Safety and biodistribution study of bone marrow-derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model.
Mäkelä T, Takalo R, Arvola O, Haapanen H, Yannopoulos F, Blanco R, Ahvenjärvi L, Kiviluoma K, Kerkelä E, Nystedt J, Juvonen T, Lehenkari P. Mäkelä T, et al. Among authors: kerkela e. Cytotherapy. 2015 Apr;17(4):392-402. doi: 10.1016/j.jcyt.2014.12.004. Epub 2015 Jan 15. Cytotherapy. 2015. PMID: 25601140
Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22.
Hyvärinen K, Holopainen M, Skirdenko V, Ruhanen H, Lehenkari P, Korhonen M, Käkelä R, Laitinen S, Kerkelä E. Hyvärinen K, et al. Among authors: kerkela e. Front Immunol. 2018 Apr 12;9:771. doi: 10.3389/fimmu.2018.00771. eCollection 2018. Front Immunol. 2018. PMID: 29706969 Free PMC article.
Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells.
Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S. Holopainen M, et al. Among authors: kerkela e. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1350-1362. doi: 10.1016/j.bbalip.2019.06.010. Epub 2019 Jun 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31207356
51 results