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Th17 cells are long lived and retain a stem cell-like molecular signature.
Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L, Sukumar M, Reger RN, Yu Z, Kern SJ, Roychoudhuri R, Ferreyra GA, Shen W, Durum SK, Feigenbaum L, Palmer DC, Antony PA, Chan CC, Laurence A, Danner RL, Gattinoni L, Restifo NP. Muranski P, et al. Among authors: kerkar sp. Immunity. 2011 Dec 23;35(6):972-85. doi: 10.1016/j.immuni.2011.09.019. Epub 2011 Dec 15. Immunity. 2011. PMID: 22177921 Free PMC article.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Hinrichs CS, Borman ZA, Gattinoni L, Yu Z, Burns WR, Huang J, Klebanoff CA, Johnson LA, Kerkar SP, Yang S, Muranski P, Palmer DC, Scott CD, Morgan RA, Robbins PF, Rosenberg SA, Restifo NP. Hinrichs CS, et al. Among authors: kerkar sp. Blood. 2011 Jan 20;117(3):808-14. doi: 10.1182/blood-2010-05-286286. Epub 2010 Oct 22. Blood. 2011. PMID: 20971955 Free PMC article.
Collapse of the tumor stroma is triggered by IL-12 induction of Fas.
Kerkar SP, Leonardi AJ, van Panhuys N, Zhang L, Yu Z, Crompton JG, Pan JH, Palmer DC, Morgan RA, Rosenberg SA, Restifo NP. Kerkar SP, et al. Mol Ther. 2013 Jul;21(7):1369-77. doi: 10.1038/mt.2013.58. Epub 2013 Apr 9. Mol Ther. 2013. PMID: 23568260 Free PMC article.
36 results