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Efflux-mediated antifungal drug resistance.
Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, Keniya MV, Tanabe K, Niimi M, Goffeau A, Monk BC. Cannon RD, et al. Among authors: keniya mv. Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents. doi: 10.1128/CMR.00051-08. Clin Microbiol Rev. 2009. PMID: 19366916 Free PMC article. Review.
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
Holmes AR, Keniya MV, Ivnitski-Steele I, Monk BC, Lamping E, Sklar LA, Cannon RD. Holmes AR, et al. Among authors: keniya mv. Antimicrob Agents Chemother. 2012 Mar;56(3):1508-15. doi: 10.1128/AAC.05706-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203607 Free PMC article.
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. Monk BC, et al. Among authors: keniya mv. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi: 10.1073/pnas.1324245111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24613931 Free PMC article.
Targeting efflux pumps to overcome antifungal drug resistance.
Holmes AR, Cardno TS, Strouse JJ, Ivnitski-Steele I, Keniya MV, Lackovic K, Monk BC, Sklar LA, Cannon RD. Holmes AR, et al. Among authors: keniya mv. Future Med Chem. 2016 Aug;8(12):1485-501. doi: 10.4155/fmc-2016-0050. Epub 2016 Jul 27. Future Med Chem. 2016. PMID: 27463566 Free PMC article. Review.
24 results