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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL. Krumm BE, et al. Among authors: kenakin t. Biochemistry. 2023 Apr 4;62(7):1233-1248. doi: 10.1021/acs.biochem.3c00029. Epub 2023 Mar 14. Biochemistry. 2023. PMID: 36917754
Structural insights into the human niacin receptor HCA2-Gi signalling complex.
Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ. Yang Y, et al. Among authors: kenakin t. Nat Commun. 2023 Mar 27;14(1):1692. doi: 10.1038/s41467-023-37177-6. Nat Commun. 2023. PMID: 36973264 Free PMC article.
Bias translation: The final frontier?
Kenakin T. Kenakin T. Br J Pharmacol. 2024 May;181(9):1345-1360. doi: 10.1111/bph.16335. Epub 2024 Feb 29. Br J Pharmacol. 2024. PMID: 38424747 Review.
Allostery: The Good, the Bad, and the Ugly.
Kenakin T. Kenakin T. J Pharmacol Exp Ther. 2024 Jan 2;388(1):110-120. doi: 10.1124/jpet.123.001838. J Pharmacol Exp Ther. 2024. PMID: 37918859 Review.
Intracellular allosteric antagonist of the olfactory receptor OR51E2.
Abaffy T, Fu O, Harume-Nagai M, Goldenberg JM, Kenyon V, Kenakin T. Abaffy T, et al. Among authors: kenakin t. Mol Pharmacol. 2024 May 6:MOLPHARM-AR-2023-000843. doi: 10.1124/molpharm.123.000843. Online ahead of print. Mol Pharmacol. 2024. PMID: 38719475 Free article.
Community guidelines for GPCR ligand bias: IUPHAR review 32.
Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Kolb P, et al. Among authors: kenakin t. Br J Pharmacol. 2022 Jul;179(14):3651-3674. doi: 10.1111/bph.15811. Epub 2022 Mar 27. Br J Pharmacol. 2022. PMID: 35106752 Free PMC article. Review.
Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.
Nguyen T, Gamage TF, Finlay DB, Decker AM, Langston TL, Barrus D, Glass M, Li JX, Kenakin TP, Zhang Y. Nguyen T, et al. Among authors: kenakin tp. J Med Chem. 2022 Jan 13;65(1):257-270. doi: 10.1021/acs.jmedchem.1c01432. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34929081 Free PMC article.
224 results