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C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
EMBO J. 2022 Jan 4;41(1):e105026. doi: 10.15252/embj.2020105026. Epub 2021 Nov 18.
EMBO J. 2022.
PMID: 34791698
Free PMC article.
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Atilano ML, Grönke S, Niccoli T, Kempthorne L, Hahn O, Morón-Oset J, Hendrich O, Dyson M, Adams ML, Hull A, Salcher-Konrad MT, Monaghan A, Bictash M, Glaria I, Isaacs AM, Partridge L.
Atilano ML, et al. Among authors: kempthorne l.
Elife. 2021 Mar 19;10:e58565. doi: 10.7554/eLife.58565.
Elife. 2021.
PMID: 33739284
Free PMC article.
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AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.
Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H.
Soutar MPM, et al. Among authors: kempthorne l.
Sci Rep. 2018 Jun 11;8(1):8855. doi: 10.1038/s41598-018-26949-6.
Sci Rep. 2018.
PMID: 29891871
Free PMC article.
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FBS/BSA media concentration determines CCCP's ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.
Soutar MPM, Kempthorne L, Annuario E, Luft C, Wray S, Ketteler R, Ludtmann MHR, Plun-Favreau H.
Soutar MPM, et al. Among authors: kempthorne l.
Autophagy. 2019 Nov;15(11):2002-2011. doi: 10.1080/15548627.2019.1603549. Epub 2019 May 7.
Autophagy. 2019.
PMID: 31060423
Free PMC article.
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Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW.
Kempthorne L, et al.
Acta Neuropathol Commun. 2020 Jun 24;8(1):90. doi: 10.1186/s40478-020-00970-1.
Acta Neuropathol Commun. 2020.
PMID: 32580749
Free PMC article.
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Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW.
Kempthorne L, et al.
Acta Neuropathol Commun. 2020 May 19;8(1):72. doi: 10.1186/s40478-020-00947-0.
Acta Neuropathol Commun. 2020.
PMID: 32430064
Free PMC article.
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