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High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status.
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. Takalo M, et al. J Nutr Biochem. 2014 Jun;25(6):634-41. doi: 10.1016/j.jnutbio.2014.02.003. Epub 2014 Mar 12. J Nutr Biochem. 2014. PMID: 24746833
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.
Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. Wittrahm R, et al. Neurobiol Dis. 2023 Jun 15;182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. Neurobiol Dis. 2023. PMID: 37120095 Free article.
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.
Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H. Kemppainen S, et al. Neurobiol Aging. 2012 Jun;33(6):1122.e23-39. doi: 10.1016/j.neurobiolaging.2011.11.006. Epub 2011 Dec 30. Neurobiol Aging. 2012. PMID: 22209410
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E. Rantamäki T, et al. PLoS One. 2013 Jul 3;8(7):e68722. doi: 10.1371/journal.pone.0068722. Print 2013. PLoS One. 2013. PMID: 23844236 Free PMC article.
23 results