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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
Yarova PL, Stewart AL, Sathish V, Britt RD Jr, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. Yarova PL, et al. Among authors: kemp pj. Sci Transl Med. 2015 Apr 22;7(284):284ra60. doi: 10.1126/scitranslmed.aaa0282. Epub 2015 Apr 22. Sci Transl Med. 2015. PMID: 25904744 Free PMC article.
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma.
Yarova PL, Huang P, Schepelmann MW, Bruce R, Ecker R, Nica R, Telezhkin V, Traini D, Gomes Dos Reis L, Kidd EJ, Ford WR, Broadley KJ, Kariuki BM, Corrigan CJ, Ward JPT, Kemp PJ, Riccardi D. Yarova PL, et al. Among authors: kemp pj. J Pharmacol Exp Ther. 2021 Jan;376(1):51-63. doi: 10.1124/jpet.120.000281. Epub 2020 Oct 28. J Pharmacol Exp Ther. 2021. PMID: 33115824
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.
Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D. Schepelmann M, et al. Among authors: kemp pj. Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C193-204. doi: 10.1152/ajpcell.00248.2015. Epub 2015 Nov 4. Am J Physiol Cell Physiol. 2016. PMID: 26538090 Free PMC article.
112 results