Kemp BE - Search Results

1

AMPK functions as an adenylate charge-regulated protein kinase.

Oakhill JS, Scott JW, Kemp BE. Oakhill JS, et al. Among authors: kemp be. Trends Endocrinol Metab. 2012 Mar;23(3):125-32. doi: 10.1016/j.tem.2011.12.006. Epub 2012 Jan 26. Trends Endocrinol Metab. 2012. PMID: 22284532 Review.

2

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, Iseli TJ, Koay A, Gooley PR, Stapleton D, Kemp BE. Scott JW, et al. Among authors: kemp be. Chem Biol. 2008 Nov 24;15(11):1220-30. doi: 10.1016/j.chembiol.2008.10.005. Chem Biol. 2008. PMID: 19022182

3

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. Oakhill JS, et al. Among authors: kemp be. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974912 Free PMC article.

4

AMPK is a direct adenylate charge-regulated protein kinase.

Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE. Oakhill JS, et al. Among authors: kemp be. Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094. Science. 2011. PMID: 21680840

5

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG. Scott JW, et al. Among authors: kemp be. Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8. Biochem Biophys Res Commun. 2014. PMID: 24332941

6

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

Scott JW, Ling N, Issa SM, Dite TA, O'Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Among authors: kemp be. Chem Biol. 2014 May 22;21(5):619-27. doi: 10.1016/j.chembiol.2014.03.006. Epub 2014 Apr 17. Chem Biol. 2014. PMID: 24746562

7

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.

Ford RJ, Fullerton MD, Pinkosky SL, Day EA, Scott JW, Oakhill JS, Bujak AL, Smith BK, Crane JD, Blümer RM, Marcinko K, Kemp BE, Gerstein HC, Steinberg GR. Ford RJ, et al. Among authors: kemp be. Biochem J. 2015 May 15;468(1):125-32. doi: 10.1042/BJ20150125. Biochem J. 2015. PMID: 25742316 Free PMC article.

8

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Among authors: kemp be. Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011. Chem Biol. 2015. PMID: 26091167

9

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. Langendorf CG, et al. Among authors: kemp be. Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912. Nat Commun. 2016. PMID: 26952388 Free PMC article.

10

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. Ali N, et al. Among authors: kemp be. Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417. Sci Rep. 2016. PMID: 28000716 Free PMC article.

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